About: SUN domain

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SUN (Sad1p, UNC-84) domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton which enables mechanosensory roles in cells. SUN proteins are thought to localize to the inner nuclear membrane. The S. pombe Sad1 protein localises at the spindle pole body. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The

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dbo:abstract
  • SUN (Sad1p, UNC-84) domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton which enables mechanosensory roles in cells. SUN proteins are thought to localize to the inner nuclear membrane. The S. pombe Sad1 protein localises at the spindle pole body. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm. (en)
  • SUN结构域（英語：SUN domain）是一种保守的C-末端蛋白结构域，名称来自：Sad1p，UNC-84 的首字母缩写，长度不到100个氨基酸残基，常位于跨膜区的附近，可与含有KASH结构域的蛋白质相互作用。 (zh)
dbo:symbol
  • Sad1_UNC
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  • 8171773 (xsd:integer)
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  • 3206 (xsd:nonNegativeInteger)
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  • 1032107457 (xsd:integer)
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  • IPR012919 (en)
dbp:name
  • Sad1_UNC (en)
dbp:pfam
  • PF07738 (en)
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  • CL0202 (en)
dbp:symbol
  • Sad1_UNC (en)
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rdfs:comment
  • SUN结构域（英語：SUN domain）是一种保守的C-末端蛋白结构域，名称来自：Sad1p，UNC-84 的首字母缩写，长度不到100个氨基酸残基，常位于跨膜区的附近，可与含有KASH结构域的蛋白质相互作用。 (zh)
  • SUN (Sad1p, UNC-84) domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton which enables mechanosensory roles in cells. SUN proteins are thought to localize to the inner nuclear membrane. The S. pombe Sad1 protein localises at the spindle pole body. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The (en)
rdfs:label
  • SUN domain (en)
  • SUN结构域 (zh)
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