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- SHR9352 is a drug which acts as a potent and selective biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It was structurally derived from oliceridine by replacing the benzylic side chain with a cyclised group, although only some compounds in the series retained the desired biased agonist profile, with some derivatives such as compound 12 being potent, unbiased μ-opioid full agonists. (en)
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- 2163 (xsd:nonNegativeInteger)
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- -N-[2-[-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]spiro[1,3-dithiolane-2,4'-2,3-dihydro-1H-naphthalene]-1'-amine (en)
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- C1CCC2C[C@]C6=CC=CC=N6 (en)
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- WRBLHOVSELHRMG-AZGAKELHSA-N (en)
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- SHR9352 is a drug which acts as a potent and selective biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It was structurally derived from oliceridine by replacing the benzylic side chain with a cyclised group, although only some compounds in the series retained the desired biased agonist profile, with some derivatives such as compound 12 being potent, unbiased μ-opioid full agonists. (en)
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