About: S-777,469

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

S-777,469 is a drug developed by Shionogi which is a cannabinoid receptor agonist, with 128x selectivity for the CB2 subtype, having a CB2 affinity of 36nM, and a CB1 affinity over 4600nM. In animal studies it showed antipruritic effects, and passed Phase II human trials for the treatment of atopic dermatitis, but development was ultimately not continued further.

Property	Value
dbo:abstract	S-777,469 is a drug developed by Shionogi which is a cannabinoid receptor agonist, with 128x selectivity for the CB2 subtype, having a CB2 affinity of 36nM, and a CB1 affinity over 4600nM. In animal studies it showed antipruritic effects, and passed Phase II human trials for the treatment of atopic dermatitis, but development was ultimately not continued further. (en)
dbo:casNumber	885496-53-7
dbo:chEMBL	2019090
dbo:fdaUniiCode	88NI79737I
dbo:pubchem	57331749
dbo:thumbnail	wiki-commons:Special:FilePath/S-777469_structure.png?width=300
dbo:wikiPageID	66024164 (xsd:integer)
dbo:wikiPageLength	3403 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1096870482 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Cannabinoid_receptor dbr:Animal_studies dbr:Antipruritic dbc:Cannabinoids dbc:Nitrogen_heterocycles dbr:S-444,823 dbr:Shionogi dbr:BMS-F dbr:Atopic_dermatitis dbr:RQ-00202730 dbr:Cannabinoid_receptor_1 dbr:Cannabinoid_receptor_2 dbr:Human_trial dbr:6-ethyl-1-[(4-fluorophenyl)methyl]-5-m...yclohexane-1-carboxylic_acid</nowiki>
dbp:atcPrefix	none (en)
dbp:c	23 (xsd:integer)
dbp:casNumber	885496 (xsd:integer)
dbp:chembl	2019090 (xsd:integer)
dbp:f	1 (xsd:integer)
dbp:h	27 (xsd:integer)
dbp:iupacName	1 (xsd:integer)
dbp:n	2 (xsd:integer)
dbp:o	4 (xsd:integer)
dbp:pubchem	57331749 (xsd:integer)
dbp:smiles	CCC1=CC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	JIYXOJFSPOFZPY-UHFFFAOYSA-N (en)
dbp:unii	88 (xsd:integer)
dbp:width	260 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Cannabinoid-stub dbt:Cannabinoids dbt:Drugbox dbt:Reflist dbt:Short_description
dcterms:subject	dbc:Cannabinoids dbc:Nitrogen_heterocycles
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	S-777,469 is a drug developed by Shionogi which is a cannabinoid receptor agonist, with 128x selectivity for the CB2 subtype, having a CB2 affinity of 36nM, and a CB1 affinity over 4600nM. In animal studies it showed antipruritic effects, and passed Phase II human trials for the treatment of atopic dermatitis, but development was ultimately not continued further. (en)
rdfs:label	S-777,469 (en)
owl:sameAs	wikidata:S-777,469 https://global.dbpedia.org/id/2YZ9b
prov:wasDerivedFrom	wikipedia-en:S-777,469?oldid=1096870482&ns=0
foaf:depiction	wiki-commons:Special:FilePath/S-777469_structure.png
foaf:isPrimaryTopicOf	wikipedia-en:S-777,469
is dbo:wikiPageRedirects of	dbr:S-777469
is dbo:wikiPageWikiLink of	dbr:S-444,823 dbr:BMS-F dbr:S-777469
is foaf:primaryTopic of	wikipedia-en:S-777,469