About: Repulsive guidance molecule

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.

Property Value
dbo:abstract
  • Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth. (en)
dbo:arm
  • q
dbo:band
  • 21.1
  • 21.2
  • 26.1
dbo:chromosome
  • 1
  • 5
  • 15
dbo:entrezgene
  • 148738
  • 285704
  • 56963
dbo:hgncid
  • 4887
  • 26896
  • 30308
dbo:omim
  • 607362 (xsd:integer)
  • 608374 (xsd:integer)
  • 612687 (xsd:integer)
dbo:refseq
  • NM_020211
  • NM_145277
  • NM_173670
dbo:symbol
  • DRAGON
  • HFE2
  • RGM
  • RGMA
  • RGMB
  • RGMC, HJV, hemojuvelin
dbo:uniprot
  • Q6NW40
  • Q6ZVN8
  • Q96B86
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  • 18156469 (xsd:integer)
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dbp:altsymbols
  • DRAGON (en)
  • RGM (en)
  • RGMC, HJV, hemojuvelin (en)
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  • q (en)
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  • 21.100000 (xsd:double)
  • 21.200000 (xsd:double)
  • 26.100000 (xsd:double)
dbp:chromosome
  • 1 (xsd:integer)
  • 5 (xsd:integer)
  • 15 (xsd:integer)
dbp:entrezgene
  • 56963 (xsd:integer)
  • 148738 (xsd:integer)
  • 285704 (xsd:integer)
dbp:hgncid
  • 4887 (xsd:integer)
  • 26896 (xsd:integer)
  • 30308 (xsd:integer)
dbp:name
dbp:omim
  • 607362 (xsd:integer)
  • 608374 (xsd:integer)
  • 612687 (xsd:integer)
dbp:refseq
  • NM_020211 (en)
  • NM_145277 (en)
  • NM_173670 (en)
dbp:symbol
dbp:uniprot
  • Q6NW40 (en)
  • Q6ZVN8 (en)
  • Q96B86 (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth. (en)
rdfs:label
  • Repulsive guidance molecule (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
foaf:name
  • RGM domain family, member A (en)
  • RGM domain family, member B (en)
  • hemochromatosis type 2 (en)
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
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