About: Receptor activity-modifying protein

Property	Value
dbo:abstract	Rezeptoraktivität-modifizierende Proteine (Receptor activity-modifying proteins, kurz RAMPs) sind Proteine, die durch Dimerisierung mit einem G-Protein-gekoppelten Rezeptor seine Konformation und somit seinen zellulären Transport steuern. Derzeit sind fünf verschiedene Rezeptoraktivität-modifizierende Proteine bekannt: RAMP1, RAMP2, RAMP3, RAMP4 und RAMP5. Durch ihre Anbindung kann jedoch nicht nur ein Transport des Rezeptors zur Zellmembran erreicht werden, sondern auch die Funktion des Rezeptors selbst moduliert werden. Ein Beispiel dafür ist der (calcitonin receptor-like receptor), der in Gegenwart von RAMP1 als Rezeptor für das Calcitonin Gene-Related Peptide (Calcitonin-Gene-Related-Peptide-Rezeptor) und in Anwesenheit von RAMP2 als Rezeptor für Adrenomedullin fungiert. (de) Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G protein-coupled receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs in mammals (though more in fish), designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene. (en)
dbo:arm	q
dbo:band	12 36 13
dbo:chromosome	2 7 17
dbo:entrezgene	10266 10267 10268
dbo:hgncid	9844 9843 9845
dbo:locusSupplementaryData	-21.1 -p12 -37.1
dbo:omim	605153 (xsd:integer) 605154 (xsd:integer) 605155 (xsd:integer)
dbo:refseq	NM_005854 NM_005855 NM_005856
dbo:symbol	RAMP RAMP1 RAMP2 RAMP3
dbo:uniprot	O60894 O60895 O60896
dbo:wikiPageExternalLink	http://www.iuphar-db.org/GPCR/ChapterMenuForward%3FchapterID=1358
dbo:wikiPageID	11071759 (xsd:integer)
dbo:wikiPageLength	6139 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1115911716 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Endoplasmic_reticulum dbr:Amylin dbr:Secretin_receptor dbr:GPCR dbr:Calcitonin_receptor dbr:RAMP2 dbr:Glucagon_receptor dbr:Golgi_apparatus dbr:Knockout_mouse dbc:Single-pass_transmembrane_proteins dbr:Adrenomedullin dbr:CALCRL dbr:Phenotype dbr:Vasoactive_intestinal_peptide_receptor dbr:RAMP1 dbr:RAMP3 dbr:CGRP
dbp:arm	q (en)
dbp:band	12 (xsd:integer) 13 (xsd:integer) 36 (xsd:integer)
dbp:chromosome	2 (xsd:integer) 7 (xsd:integer) 17 (xsd:integer)
dbp:entrezgene	10266 (xsd:integer) 10267 (xsd:integer) 10268 (xsd:integer)
dbp:hgncid	9843 (xsd:integer) 9844 (xsd:integer) 9845 (xsd:integer)
dbp:interpro	IPR006985 (en)
dbp:locussupplementarydata	-37.100000 (xsd:double) -21.100000 (xsd:double) -p12 (en)
dbp:membranomeSuperfamily	10 (xsd:integer)
dbp:name	Receptor activity-modifying protein (en) Receptor activity-modifying protein 1 (en) Receptor activity-modifying protein 2 (en) Receptor activity-modifying protein 3 (en)
dbp:omim	605153 (xsd:integer) 605154 (xsd:integer) 605155 (xsd:integer)
dbp:pfam	PF04901 (en)
dbp:refseq	NM_005854 (en) NM_005855 (en) NM_005856 (en)
dbp:symbol	dbr:RAMP2 dbr:RAMP1 dbr:RAMP3 RAMP (en)
dbp:uniprot	O60894 (en) O60895 (en) O60896 (en)
dbp:width	500 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Cite_web dbt:Infobox_protein_family dbt:MeshName dbt:More_citations_needed_section dbt:Protein-stub dbt:Reflist dbt:Short_description dbt:Growth_factor_receptor_modulators dbt:Infobox_protein dbt:Neuropeptide_receptors
dcterms:subject	dbc:Single-pass_transmembrane_proteins
gold:hypernym	dbr:Protein
rdf:type	owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatTransportProteins yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinGroups
rdfs:comment	Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G protein-coupled receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs in mammals (though more in fish), designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene. (en) Rezeptoraktivität-modifizierende Proteine (Receptor activity-modifying proteins, kurz RAMPs) sind Proteine, die durch Dimerisierung mit einem G-Protein-gekoppelten Rezeptor seine Konformation und somit seinen zellulären Transport steuern. Derzeit sind fünf verschiedene Rezeptoraktivität-modifizierende Proteine bekannt: RAMP1, RAMP2, RAMP3, RAMP4 und RAMP5. (de)
rdfs:label	Rezeptoraktivität-modifizierende Proteine (de) Receptor activity-modifying protein (en)
owl:sameAs	freebase:Receptor activity-modifying protein yago-res:Receptor activity-modifying protein wikidata:Receptor activity-modifying protein dbpedia-de:Receptor activity-modifying protein https://global.dbpedia.org/id/xW7V
prov:wasDerivedFrom	wikipedia-en:Receptor_activity-modifying_protein?oldid=1115911716&ns=0
foaf:isPrimaryTopicOf	wikipedia-en:Receptor_activity-modifying_protein
foaf:name	Receptor activity-modifying protein 1 (en) Receptor activity-modifying protein 2 (en) Receptor activity-modifying protein 3 (en)
is dbo:wikiPageDisambiguates of	dbr:Ramp_(disambiguation)
is dbo:wikiPageWikiLink of	dbr:EGF-like_domain dbr:Amylin dbr:Calcitonin_gene-related_peptide dbr:Calcitonin_receptor dbr:GPR182 dbr:RAMP2 dbr:Ramp_(disambiguation) dbr:Adrenomedullin dbr:Sushi_domain dbr:CALCRL dbr:RAMP1 dbr:RAMP3
is foaf:primaryTopic of	wikipedia-en:Receptor_activity-modifying_protein