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A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially engineered protein receptors used in the field of chemogenetics which are selectively activated by certain ligands. They are used in biomedical research, in particular in neuroscience to manipulate the activity of neurons.

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  • A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially engineered protein receptors used in the field of chemogenetics which are selectively activated by certain ligands. They are used in biomedical research, in particular in neuroscience to manipulate the activity of neurons. Originally differentiated by the approach used to engineer them, RASSLs and DREADDs are often used interchangeably now to represent an engineered receptor-ligand system. These systems typically utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), and not to endogenous ligands. Several types of these receptors exists, derived from muscarinic or κ-opioid receptors. (en)
  • En neurosciences, les DREADD (pour Designer Receptor Exclusively Activated by Designer Drugs) aussi connus sous le nom de RASSL (Receptor activated solely by a synthetic ligand) sont des constructions moléculaires basés sur des récepteurs à protéine G et créés de façon à n'être sensibles qu'à une molécule ligand qui n'est pas présente naturellement dans l'organisme. Cela permet de contrôler temporellement et spatialement leur activation en injectant, au moment et dans la zone voulus par l'expérimentateur, le ligand de synthèse, typiquement une N-oxide clozapine (CNO). Cela en fait donc un outil précieux pour manipuler in vivo des neurones de façon contrôlée. * Portail de la médecine (fr)
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  • A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially engineered protein receptors used in the field of chemogenetics which are selectively activated by certain ligands. They are used in biomedical research, in particular in neuroscience to manipulate the activity of neurons. (en)
  • En neurosciences, les DREADD (pour Designer Receptor Exclusively Activated by Designer Drugs) aussi connus sous le nom de RASSL (Receptor activated solely by a synthetic ligand) sont des constructions moléculaires basés sur des récepteurs à protéine G et créés de façon à n'être sensibles qu'à une molécule ligand qui n'est pas présente naturellement dans l'organisme. Cela permet de contrôler temporellement et spatialement leur activation en injectant, au moment et dans la zone voulus par l'expérimentateur, le ligand de synthèse, typiquement une N-oxide clozapine (CNO). Cela en fait donc un outil précieux pour manipuler in vivo des neurones de façon contrôlée. (fr)
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  • Designer Receptor Exclusively Activated by Designer Drugs (fr)
  • Receptor activated solely by a synthetic ligand (en)
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