About: RTIOX-276

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine.

Property	Value
dbo:abstract	RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine. (en)
dbo:thumbnail	wiki-commons:Special:FilePath/RTIOX-276_Structure.svg?width=300
dbo:wikiPageID	67063166 (xsd:integer)
dbo:wikiPageLength	2604 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1120556027 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Orexin_antagonist dbr:Cocaine dbr:Conditioned_place_preference dbc:3-Pyridyl_compounds dbc:Amides dbc:Benzylisoquinolines dbc:Orexin_antagonists dbr:Affinity_(pharmacology) dbr:Binding_selectivity dbr:Orexin_1_receptor dbr:Orexin_2_receptor dbr:Cocaine_addiction
dbp:c	29 (xsd:integer)
dbp:f	3 (xsd:integer)
dbp:h	32 (xsd:integer)
dbp:iupacName	2 (xsd:integer)
dbp:n	3 (xsd:integer)
dbp:o	5 (xsd:integer)
dbp:smiles	O=CCN2CC4=CC=CC=C4CC2 (en)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Sedative-stub dbt:Orexin_receptor_modulators
dcterms:subject	dbc:3-Pyridyl_compounds dbc:Amides dbc:Benzylisoquinolines dbc:Orexin_antagonists
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine. (en)
rdfs:label	RTIOX-276 (en)
owl:sameAs	wikidata:RTIOX-276 https://global.dbpedia.org/id/Fq8mP
prov:wasDerivedFrom	wikipedia-en:RTIOX-276?oldid=1120556027&ns=0
foaf:depiction	wiki-commons:Special:FilePath/RTIOX-276_Structure.svg
foaf:isPrimaryTopicOf	wikipedia-en:RTIOX-276
is dbo:wikiPageWikiLink of	dbr:Orexin_antagonist dbr:Hypocretin_(orexin)_receptor_1 dbr:Orexin_receptor dbr:List_of_signaling_peptide/protein_receptor_modulators
is foaf:primaryTopic of	wikipedia-en:RTIOX-276