About: Quinupramine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.

Property	Value
dbo:abstract	Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor. Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself. (en)
dbo:casNumber	31721-17-2
dbo:fdaUniiCode	29O61HFF4L
dbo:kegg	D07336
dbo:pubchem	93154
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dbp:atcPrefix	N06 (en)
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dbp:eliminationHalfLife	118800.0
dbp:h	24 (xsd:integer)
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dbp:kegg	D07336 (en)
dbp:legalStatus	Rx-only (en)
dbp:n	2 (xsd:integer)
dbp:pubchem	93154 (xsd:integer)
dbp:routesOfAdministration	Oral (en)
dbp:title	dbr:Pharmacodynamics
dbp:titlestyle	background:#ccccff (en)
dbp:unii	29 (xsd:integer)
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gold:hypernym	dbr:Antidepressant
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rdfs:comment	Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor. (en)
rdfs:label	Quinupramine (en)
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