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- La piruvato deshidrogenasa cinasa (PDK) EC 2.7.11.2 es una enzima que cataliza la reacción de fosforilación de la piruvato deshidrogenasa-(acetil transferidora) (PDH). El ATP transfiere su grupo fosfato a la enzima dando lugar a la aparición de un ADP. PDH + ATP PDH-fosfato + ADP Esta reacción inhibe el complejo piruvato deshidrogenasa actuando sobre la cadena alfa de la PDH, por tanto contribuye a la regulación del metabolismo de la glucosa. La localización celular de la enzima es la matriz mitocondrial. (es)
- La pyruvate déshydrogénase kinase ou PDHK est une classe d'enzymes inhibant la pyruvate déshydrogénase. Le pyruvate ne peut donc plus être transformé en acétyl-coenzyme A mais passe par la voie de la lactate déshydrogénase pour se transformer en lactates. La PDHK existe sous quatre isoformes, (en), (en), (en) et (en), chacun ayant une affinité différente sur les trois sites de phosphorylation de la pyruvate déshydrogénase. Pyruvate déshydrogénase kinase (fr)
- Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. PDK thus participates in the regulation of the pyruvate dehydrogenase complex of which pyruvate dehydrogenase is the first component. Both PDK and the pyruvate dehydrogenase complex are located in the mitochondrial matrix of eukaryotes. The complex acts to convert pyruvate (a product of glycolysis in the cytosol) to acetyl-coA, which is then oxidized in the mitochondria to produce energy, in the citric acid cycle. By downregulating the activity of this complex, PDK will decrease the oxidation of pyruvate in mitochondria and increase the conversion of pyruvate to lactate in the cytosol. The opposite action of PDK, namely the dephosphorylation and activation of pyruvate dehydrogenase, is catalyzed by a phosphoprotein phosphatase called pyruvate dehydrogenase phosphatase. (Pyruvate dehydrogenase kinase should not be confused with Phosphoinositide-dependent kinase-1, which is also sometimes known as "PDK1".) (en)
- Kinase piruvat dehidrogenase (bahasa Inggris: pyruvate dehydrogenase kinase, PDK, EC 2.7.11.2) merupakan enzim regulasi dalam kompleks piruvat dehidrogenase. Gen ini adalah salah satu gen dari keluarga protein kinase PDK/BCKDK dan mengkodekan protein mitokondria dengan domain . Protein ini terletak di matriks mitokondria dan menghambat piruvat dehidrogenase complex dengan fosforilasi salah satu subunitnya. Dengan demikian PDK berperan dalam regulasi metabolisme glukosa. Ekspresi gen ini diregulasi oleh glukokortikoid, asam retinoat, dan insulin. PDK dihambat secara oleh konsentrasi asam piruvat yang tinggi, sedangkan kinase diaktifkan dengan asetil-KoA: Ko-A dan NADH:NAD+ yang tinggi pada mitokondria.Otot lurik mengekspresikan dua (PDK2 dan PDK4) dari empat PDK ysng diekspresikan pada sel mamalia (PDK1-4). Peningkatan PDK dengan kelaparan dan diabetes disebabkan karena peningkatan selektif regulasi ekspresi PDK4. Peningkatan regulasi ini disebabkan karena peningkatan asam lemak bebas (FFA). (in)
- Piruvato desidrogenase quinase (também piruvato desidrogenase complexo quinase, PDC quinase, ou PDK (do inglês pyruvate dehydrogenase kinase). Classificada com número EC 2.7.11.2, é uma enzima quinase a qual atua inativando a enzima piruvato desidrogenase por fosforilação por meio de ATP. PDK participa na regulação do da qual piruvato dehidrogenase é o primeiro componente. Tanto PDK e o complexo piruvato dehidrogenase estão localizados na dos eucariotas. O complexo atua em converter piruvato (um produto da glicólise no citosol) a acetilcoenzima A ou "acetil-coA", a qual então é oxidada na mitocôndria para produzir energia, no ciclo de ácido cítrico, também chamado ciclo de Krebs. Por atuar limitando a atividade deste complexo, PDK irá diminuir a oxidação de piruvato na mitocôndra e aumenta a conversão de piruvato em lactato no citosol. A ação opsta do PDK, nomeada a defosforilação e ativação da piruvato desidrogenase, é catalisada por uma chamada . (pt)
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- 14479 (xsd:nonNegativeInteger)
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- The areas around the three phosphorylation sites are shown in red. Site 1 is in the bottom left corner, site 2 in the top right, and site 3 in the bottom right. (en)
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- Pyruvate dehydrogenase kinase (en)
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- La piruvato deshidrogenasa cinasa (PDK) EC 2.7.11.2 es una enzima que cataliza la reacción de fosforilación de la piruvato deshidrogenasa-(acetil transferidora) (PDH). El ATP transfiere su grupo fosfato a la enzima dando lugar a la aparición de un ADP. PDH + ATP PDH-fosfato + ADP Esta reacción inhibe el complejo piruvato deshidrogenasa actuando sobre la cadena alfa de la PDH, por tanto contribuye a la regulación del metabolismo de la glucosa. La localización celular de la enzima es la matriz mitocondrial. (es)
- La pyruvate déshydrogénase kinase ou PDHK est une classe d'enzymes inhibant la pyruvate déshydrogénase. Le pyruvate ne peut donc plus être transformé en acétyl-coenzyme A mais passe par la voie de la lactate déshydrogénase pour se transformer en lactates. La PDHK existe sous quatre isoformes, (en), (en), (en) et (en), chacun ayant une affinité différente sur les trois sites de phosphorylation de la pyruvate déshydrogénase. Pyruvate déshydrogénase kinase (fr)
- Kinase piruvat dehidrogenase (bahasa Inggris: pyruvate dehydrogenase kinase, PDK, EC 2.7.11.2) merupakan enzim regulasi dalam kompleks piruvat dehidrogenase. Gen ini adalah salah satu gen dari keluarga protein kinase PDK/BCKDK dan mengkodekan protein mitokondria dengan domain . Protein ini terletak di matriks mitokondria dan menghambat piruvat dehidrogenase complex dengan fosforilasi salah satu subunitnya. Dengan demikian PDK berperan dalam regulasi metabolisme glukosa. Ekspresi gen ini diregulasi oleh glukokortikoid, asam retinoat, dan insulin. PDK dihambat secara oleh konsentrasi asam piruvat yang tinggi, sedangkan kinase diaktifkan dengan asetil-KoA: Ko-A dan NADH:NAD+ yang tinggi pada mitokondria.Otot lurik mengekspresikan dua (PDK2 dan PDK4) dari empat PDK ysng diekspresikan pada se (in)
- Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. The opposite action of PDK, namely the dephosphorylation and activation of pyruvate dehydrogenase, is catalyzed by a phosphoprotein phosphatase called pyruvate dehydrogenase phosphatase. (Pyruvate dehydrogenase kinase should not be confused with Phosphoinositide-dependent kinase-1, which is also sometimes known as "PDK1".) (en)
- Piruvato desidrogenase quinase (também piruvato desidrogenase complexo quinase, PDC quinase, ou PDK (do inglês pyruvate dehydrogenase kinase). Classificada com número EC 2.7.11.2, é uma enzima quinase a qual atua inativando a enzima piruvato desidrogenase por fosforilação por meio de ATP. A ação opsta do PDK, nomeada a defosforilação e ativação da piruvato desidrogenase, é catalisada por uma chamada . (pt)
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- Piruvato deshidrogenasa cinasa (es)
- Piruvat dehidrogenase kinase (in)
- Pyruvate déshydrogénase kinase (fr)
- Pyruvate dehydrogenase kinase (en)
- Piruvato desidrogenase quinase (pt)
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- Pyruvate dehydrogenase kinase (en)
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