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- Archaeotherium was the largest and most powerful beast of the badlands until the bear dogs arrived, and is depicted evolving into the even larger Daeodon in order to survive against the new threat. (en)
- The savage dire wolf was the largest dog on the planet at the time. It is shown chasing off lone Smilodons and faceing off with short-faced bears and hunting down Bison antiquus and Mexican horses in large packs. (en)
- The huge terror birds of South and North America, Kelenken and Titanis, are both shown as apex predators. Kelenken is shown to eat Homalodotherium, glyptodonts, and rodents, and Titanis is shown coming into competition with additional predators Smilodon gracilis and Canis edwardii, and is also shown to eat horses. (en)
- The only animal who would attack an Archaeotherium was Hyaenodon, with its powerful razor jaws, until bear dogs arrived on the continent, driving both to extinction. (en)
- The huge, powerful shark C. megalodon is shown subsisting on a diet of whales. (en)
- Arctodus simus, the giant short-faced bear, was one of the largest mammalian carnivore ever to walk the Earth. The bear is shown defeating Smilodon fatalis and Megalonyx, trying to take down Mexican horses, scaring off dire wolves, and even coming into contact with early humans (en)
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