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- Phosphoribosylamine—glycine ligase, also known as glycinamide ribonucleotide synthetase (GARS), (EC 6.3.4.13) is an enzyme that catalyzes the chemical reaction ATP + 5-phospho-D-ribosylamine + glycine ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide which is the second step in purine biosynthesis.The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide. This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). The purD genes often contain PurD RNA motif in their 5' UTR. In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5/7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS). In higher eukaryotes, including humans, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART. (en)
- La fosforibosilamina glicina ligasi, o GAR sintasi (GARS), (EC 6.3.4.13) è un enzima che catalizza la reazione chimica ATP + 5-fosfo-D-ribosilamina + glicina ADP + fosfato + N1-(5-fosfo-D-ribosil)glicinammide che è il secondo step nella biosintesi delle purine. I tre substrati dell'enzima sono ATP, 5-fosfo-D-ribosilamina e glicina mentre i suoi tre prodotti sono ADP, fosfato e N1-(5-fosfo-D-ribosil)glicinammide. Questo enzima appartiene alla famiglia delle ligasi. Nei batteri, GARS è un enzima codificato del gene purD. Nei lieviti, è un enzima bifunzionale (codificato dal gene ADE5/7) insieme all'. Negli eucarioti, inclusi gli umani, GARS è parte di un enzima trifunzionale: la Proteina trifunzionale biosintetica delle purine Adenosina-3. (it)
- ホスホリボシルアミン—グリシンリガーゼ(phosphoribosylamine—glycine ligase)またはグリシンアミドリボヌクレオチドシンテターゼ(glycinamide ribonucleotide synthetase, GARS)は、ホスホリボシルアミン(PRA)とグリシンをアミド結合させ、(GAR)に変換する酵素である。プリン塩基のde novo合成経路の第2段階を担う。 ATP + 5-ホスホ-D-リボシルアミン + グリシン ADP + リン酸 + (ja)
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- 12304 (xsd:nonNegativeInteger)
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- crystal structure of phosphoribosylamine--glycine ligase from thermotoga maritima at 2.30 a resolution (en)
- phosphoribosylamine-glycine ligase monomer , Human (en)
- glycinamide ribonucleotide synthetase from e. coli. (en)
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- IPR020560 (en)
- IPR020561 (en)
- IPR020562 (en)
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- Phosphoribosylamine—glycine ligase (en)
- Phosphoribosylglycinamide synthetase, ATP-grasp domain (en)
- Phosphoribosylglycinamide synthetase, C domain (en)
- Phosphoribosylglycinamide synthetase, N domain (en)
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- PF01071 (en)
- PF02843 (en)
- PF02844 (en)
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- GARS_A (en)
- GARS_C (en)
- GARS_N (en)
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| rdfs:comment
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- ホスホリボシルアミン—グリシンリガーゼ(phosphoribosylamine—glycine ligase)またはグリシンアミドリボヌクレオチドシンテターゼ(glycinamide ribonucleotide synthetase, GARS)は、ホスホリボシルアミン(PRA)とグリシンをアミド結合させ、(GAR)に変換する酵素である。プリン塩基のde novo合成経路の第2段階を担う。 ATP + 5-ホスホ-D-リボシルアミン + グリシン ADP + リン酸 + (ja)
- Phosphoribosylamine—glycine ligase, also known as glycinamide ribonucleotide synthetase (GARS), (EC 6.3.4.13) is an enzyme that catalyzes the chemical reaction ATP + 5-phospho-D-ribosylamine + glycine ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide which is the second step in purine biosynthesis.The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide. This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. (en)
- La fosforibosilamina glicina ligasi, o GAR sintasi (GARS), (EC 6.3.4.13) è un enzima che catalizza la reazione chimica ATP + 5-fosfo-D-ribosilamina + glicina ADP + fosfato + N1-(5-fosfo-D-ribosil)glicinammide che è il secondo step nella biosintesi delle purine. I tre substrati dell'enzima sono ATP, 5-fosfo-D-ribosilamina e glicina mentre i suoi tre prodotti sono ADP, fosfato e N1-(5-fosfo-D-ribosil)glicinammide. Questo enzima appartiene alla famiglia delle ligasi. (it)
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| rdfs:label
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- Fosforibosilamina glicina ligasi (it)
- ホスホリボシルアミン—グリシンリガーゼ (ja)
- Phosphoribosylamine—glycine ligase (en)
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- Phosphoribosylamine—glycine ligase (en)
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