About: PF-04745637

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis.

Property	Value
dbo:abstract	PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis. (en)
dbo:casNumber	1917294-46-2
dbo:chEMBL	4208555
dbo:pubchem	121304827
dbo:thumbnail	wiki-commons:Special:FilePath/PF-04745637_structure.png?width=300
dbo:wikiPageID	66007428 (xsd:integer)
dbo:wikiPageLength	1704 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	995180764 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Chloroarenes dbr:TRPV1 dbr:Atopic_dermatitis dbr:Antiinflammatory dbr:TRPM dbr:TRPA1 dbr:Antagonist_(pharmacology)
dbp:c	27 (xsd:integer)
dbp:casNumber	1917294 (xsd:integer)
dbp:chembl	4208555 (xsd:integer)
dbp:cl	1 (xsd:integer)
dbp:f	3 (xsd:integer)
dbp:h	32 (xsd:integer)
dbp:iupacName	1 (xsd:integer)
dbp:n	2 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pubchem	121304827 (xsd:integer)
dbp:smiles	C1CCCCNC[C@@H]N4CCCO (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	PAEBEJVPSADOMC-HSZRJFAPSA-N (en)
dbp:width	220 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Pharm-stub dbt:Reflist dbt:Transient_receptor_potential_channel_modulators
dcterms:subject	dbc:Chloroarenes
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis. (en)
rdfs:label	PF-04745637 (en)
owl:sameAs	wikidata:PF-04745637 https://global.dbpedia.org/id/FQHN7
prov:wasDerivedFrom	wikipedia-en:PF-04745637?oldid=995180764&ns=0
foaf:depiction	wiki-commons:Special:FilePath/PF-04745637_structure.png
foaf:isPrimaryTopicOf	wikipedia-en:PF-04745637
is foaf:primaryTopic of	wikipedia-en:PF-04745637