About: Off-target activity

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Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women.

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  • Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women. (en)
  • オフターゲット活性（おふたーげっとかっせい、英: off-target activity）とは、薬物が意図した生物学的標的とは異なる生物学的活性のことである。一般的には副作用の原因となる。しかし、場合によっては、オフターゲット活性を利用して治療を行うことができる。たとえば、副作用として女性化および女性化乳房を引き起こすことが知られていたおよび利尿薬のスピロノラクトンを、抗アンドロゲン薬としてニキビや多毛症などのの治療に再利用した例がある。 (ja)
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  • Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women. (en)
  • オフターゲット活性（おふたーげっとかっせい、英: off-target activity）とは、薬物が意図した生物学的標的とは異なる生物学的活性のことである。一般的には副作用の原因となる。しかし、場合によっては、オフターゲット活性を利用して治療を行うことができる。たとえば、副作用として女性化および女性化乳房を引き起こすことが知られていたおよび利尿薬のスピロノラクトンを、抗アンドロゲン薬としてニキビや多毛症などのの治療に再利用した例がある。 (ja)
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  • オフターゲット活性 (ja)
  • Off-target activity (en)
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