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- O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit. O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms. (en)
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- 6-(Benzyloxy)guanine; 6-O-Benzylguanine; O(6)-bGua; O6-BG (en)
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- 6-(Benzyloxy)-7H-purin-2-amine (en)
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- O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit. O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms. (en)
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