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Nigeria competed at the 2022 World Athletics Championships in Eugene, United States, from 15 to 24 July 2022. The Athletics Federation of Nigeria entered 24 athletes. On 24 July 2022, Nigeria achieved its first world gold medal at the World Athletics Championships after Tobi Amusan won the women's 100 metres hurdles final. Amusan setted a new world record when she ran a 12.12 time in her semifinal heat before she bettered that in the final when she crossed the line in a time of 12.06, however, her time in the final was not considered as the new world record due to the wind reading (+2.5 MPS) was over the allowable.