A chiral shift reagent is a reagent used in analytical chemistry for determining the optical purity of a sample. Some analytical techniques such as HPLC and NMR, in their most commons forms, cannot distinguish enantiomers within a sample, but can distinguish diastereomers. Therefore, converting a mixture of enantiomers to a corresponding mixture of diastereomers can allow analysis. One method involves the reaction of a chiral derivatizing agent (CDA) with a mixture of enantiomers to produce diastereomers via covalent attachment. One of the most common CDA is Mosher's acid.
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