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- In enzymology, a NADH dehydrogenase (quinone) (EC 1.6.5.11) is an enzyme that catalyzes the chemical reaction NADH + H+ + a quinone NAD+ + a quinol The 3 substrates of this enzyme are NADH, H+, and a quinone (electron acceptor), whereas its two products are NAD+ and a quinol (reduced acceptor). This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial (mt) complex I. This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-dinitrophenol. NADH dehydrogenase is involved in the first step of the electron transport chain of oxidative phosphorylation (OXPHOS). Any change in the electron transport component caused by a mutation might effect the normal electron flow. This might be leading "an increase of bifurcation and generation of superoxidase radicals and increase oxidative stress in various types of cancer cells." In the electron transport chain NADH is mainly used to create a concentration gradient of hydrogen in order to make ATP. Since After NADH is oxidized a hydrogen is pumped out and NAD+ will be a product. (en)
- La NAD deidrogenasi (chinone) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: NADH + H+ + accettore ⇄ NAD+ + accettore ridotto L'enzima può utilizzare anche il menachinone come accettore. È inibito dall'AMP e dal 2,4-dinitrofenolo ma non dal dicumarolo o da derivati dell'acido folico. (it)
- NADHデヒドロゲナーゼ (キノン)（NADH dehydrogenase (quinone)）は、酸化的リン酸化に関与する酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 NADH + H+ + キノン NAD+ + キノール 反応式の通り、この酵素の基質はNADHとH+とキノン、生成物はNAD+とキノールである。 組織名はNADH:(quinone-acceptor) oxidoreductaseで、別名にreduced nicotinamide adenine dinucleotide (quinone) dehydrogenase、NADH-quinone oxidoreductase、DPNH-menadione reductase、D-diaphorase、NADH2 dehydrogenase (quinone)がある。 (ja)
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- 4343 (xsd:nonNegativeInteger)
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- Structure of NADH dehydrogenase . PDB entry (en)
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- La NAD deidrogenasi (chinone) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: NADH + H+ + accettore ⇄ NAD+ + accettore ridotto L'enzima può utilizzare anche il menachinone come accettore. È inibito dall'AMP e dal 2,4-dinitrofenolo ma non dal dicumarolo o da derivati dell'acido folico. (it)
- NADHデヒドロゲナーゼ (キノン)（NADH dehydrogenase (quinone)）は、酸化的リン酸化に関与する酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 NADH + H+ + キノン NAD+ + キノール 反応式の通り、この酵素の基質はNADHとH+とキノン、生成物はNAD+とキノールである。 組織名はNADH:(quinone-acceptor) oxidoreductaseで、別名にreduced nicotinamide adenine dinucleotide (quinone) dehydrogenase、NADH-quinone oxidoreductase、DPNH-menadione reductase、D-diaphorase、NADH2 dehydrogenase (quinone)がある。 (ja)
- In enzymology, a NADH dehydrogenase (quinone) (EC 1.6.5.11) is an enzyme that catalyzes the chemical reaction NADH + H+ + a quinone NAD+ + a quinol The 3 substrates of this enzyme are NADH, H+, and a quinone (electron acceptor), whereas its two products are NAD+ and a quinol (reduced acceptor). In the electron transport chain NADH is mainly used to create a concentration gradient of hydrogen in order to make ATP. Since After NADH is oxidized a hydrogen is pumped out and NAD+ will be a product. (en)
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- NAD deidrogenasi (chinone) (it)
- NADHデヒドロゲナーゼ (キノン) (ja)
- NADH dehydrogenase (quinone) (en)
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- NADH dehydrogenase (quinone) (en)
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