About: Myticin

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Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis (Mediterranean mussel). Isoforms A and B show antibacterial activity against Gram-positive bacteria, while isoform C is additionally active against the fungus Fusarium oxysporum and bacterium Escherichia coli (streptomycin resistant strain D31). Myticin-prepro is the precursor peptide.

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dbo:abstract
  • Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis (Mediterranean mussel). Isoforms A and B show antibacterial activity against Gram-positive bacteria, while isoform C is additionally active against the fungus Fusarium oxysporum and bacterium Escherichia coli (streptomycin resistant strain D31). Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulphide bridges and a cysteine array in the primary structure different from that of previously characterised cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesised as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. (en)
dbo:symbol
  • Myticin-prepro
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  • 35402112 (xsd:integer)
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  • 2161 (xsd:nonNegativeInteger)
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  • 997487861 (xsd:integer)
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dbp:caption
  • solution structure of the synthetic mytilin (en)
dbp:interpro
  • IPR019631 (en)
dbp:name
  • Myticin-prepro (en)
dbp:opmFamily
  • 58 (xsd:integer)
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  • 2 (xsd:integer)
dbp:pfam
  • PF10690 (en)
dbp:symbol
  • Myticin-prepro (en)
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rdfs:comment
  • Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis (Mediterranean mussel). Isoforms A and B show antibacterial activity against Gram-positive bacteria, while isoform C is additionally active against the fungus Fusarium oxysporum and bacterium Escherichia coli (streptomycin resistant strain D31). Myticin-prepro is the precursor peptide. (en)
rdfs:label
  • Myticin (en)
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