About: Modified vaccinia Ankara

An Entity of Type: vaccine, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU, Imvamune in Canada, and Jynneos in the US) against smallpox and monkeypox, having fewer side effects than the traditional smallpox vaccine. This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell."

Property	Value
dbo:abstract	Das Modified-Vaccinia-Ankara-Virus (MVA) ist ein abgeschwächtes (genauer: attenuiertes) Kuhpockenvirus, das zu Impfzwecken verwendet wird. (de) Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU, Imvamune in Canada, and Jynneos in the US) against smallpox and monkeypox, having fewer side effects than the traditional smallpox vaccine. This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell." By inserting antigen genes into its genome, modified vaccinia Ankara virus is also used as an experimental viral vector for vaccines against non-poxvirus diseases. (en)
dbo:alternativeName	Imvanex, Imvamune, Jynneos (en)
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dbp:legalCa	Rx-only, Schedule D (en)
dbp:legalEu	Rx-only (en)
dbp:legalUk	POM (en)
dbp:legalUs	Rx-only (en)
dbp:routesOfAdministration	dbr:Intradermal_injection dbr:Subcutaneous_injection
dbp:synonyms	MVA (en)
dbp:target	dbr:Monkeypox dbr:Smallpox
dbp:tradename	Imvanex, Imvamune, Jynneos (en)
dbp:type	vaccine (en)
dbp:vaccineType	attenuated (en)
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rdfs:comment	Das Modified-Vaccinia-Ankara-Virus (MVA) ist ein abgeschwächtes (genauer: attenuiertes) Kuhpockenvirus, das zu Impfzwecken verwendet wird. (de) Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU, Imvamune in Canada, and Jynneos in the US) against smallpox and monkeypox, having fewer side effects than the traditional smallpox vaccine. This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell." (en)
rdfs:label	Modified-Vaccinia-Ankara-Virus (de) Modified vaccinia Ankara (en)
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