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Maddrey's discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis steroid treatment. The Maddrey DF score is a predictive statistical model compares the subject's DF score with mortality prognosis within 30-day or 90-day scores. The subject's Maddrey DF score is determined by blood analysis. To calculate Maddrey discriminant function using SI units, such as micromoles per litre, divide bilirubin value by 17.

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dbo:abstract
  • El Índice de Maddrey fue originalmente descrito por Maddrey y Boitnott​ como predictor pronóstico en la hepatitis alcohólica. (es)
  • Maddrey's discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis steroid treatment. The Maddrey DF score is a predictive statistical model compares the subject's DF score with mortality prognosis within 30-day or 90-day scores. The subject's Maddrey DF score is determined by blood analysis. The modified Maddrey's discriminant function was originally described by Maddrey and Boitnott to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula using prothrombin time and serum bilirubin concentration: Prospective studies have shown that it is useful in predicting short term prognosis, especially mortality within 30 days. A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%. Corticosteroid therapy or pentoxifylline have been used with mixed results for patients whose increased mortality is indicated with a value greater than 32. To calculate Maddrey discriminant function using SI units, such as micromoles per litre, divide bilirubin value by 17. (en)
  • Wskaźnik Maddreya, DF (ang. modified Maddrey's Discriminant Function) – wskaźnik rokowniczy w alkoholowym zapaleniu wątroby, opisany przez Maddreya i Boitnotta . Nadmierne spożywanie alkoholu prowadzi do alkoholowego zapalenia wątroby, marskości wątroby, a w konsekwencji do niewydolności tego narządu. Wzór na obliczanie wskaźnika:DF = ( PT [s] – prawidłowy PT [s] ) x 4,6 + bilirubina [mg/dl]. lub DF = ( PT [s] – prawidłowy PT [s] ) x 4,6 + bilirubina [μmol/l] / 17 gdzie: * DF – wskaźnik rokowniczy (czynnik dyskryminujący) * PT – czas protrombinowy * bilirubina – stężenie bilirubiny Wartość DF > 32 oznacza ciężki stan kliniczny i duże ryzyko zgonu w ciągu 30 dni (35-45%). (pl)
  • 莫德瑞評分量表(Maddrey's discriminant function,DF)是用於評估酒精性肝炎嚴重程度及預後的傳統模式,能用於評估其嚴重程度、預後、及對類固醇治療的反應。莫氏評分量表是預測性的統計模型,用於預測患者的30天、90天死亡率。其分數計算需根據抽血檢查的實驗室數據。 修正的莫德瑞評分量表由Maddrey及Boitnott兩位學者所提出,能用於預測酒精性肝炎的預後。其分數的計算透過一個簡單的公式,所取用的參數包含:凝血酶原時間(prothrombin time,PT)及血清膽紅素(serum bilirubin)。其公式如下: ( 4.6 x (凝血酶原時間 - 凝血控制時間)) + 血清膽紅素 (mg/dL) 前瞻性研究顯示這一個公式能夠預測短期的預後,特別是30天內的死亡率。若其分數超過32顯示預後較差,且一個月死亡率為35 - 45%。類固醇、或己酮可可鹼(pentoxifylline)會被用於治療分數 > 32分且預後更差的患者,但其結果仍好壞參半。 若要使用國際單位制計算莫氏評分量表,如摩尔/公升(mmol/L),應將血清膽紅素(mg/dL)的值除以17。 (zh)
dbo:wikiPageID
  • 11424466 (xsd:integer)
dbo:wikiPageLength
  • 3843 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1123786057 (xsd:integer)
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dbp:date
  • March 2020 (en)
dbp:name
  • Modified Maddrey's discriminant function (en)
dbp:purpose
  • evaluate severity of alcoholic hepatitis (en)
dbp:reason
  • This sentence doesn't parse. (en)
dbp:wikiPageUsesTemplate
dcterms:subject
rdfs:comment
  • El Índice de Maddrey fue originalmente descrito por Maddrey y Boitnott​ como predictor pronóstico en la hepatitis alcohólica. (es)
  • 莫德瑞評分量表(Maddrey's discriminant function,DF)是用於評估酒精性肝炎嚴重程度及預後的傳統模式,能用於評估其嚴重程度、預後、及對類固醇治療的反應。莫氏評分量表是預測性的統計模型,用於預測患者的30天、90天死亡率。其分數計算需根據抽血檢查的實驗室數據。 修正的莫德瑞評分量表由Maddrey及Boitnott兩位學者所提出,能用於預測酒精性肝炎的預後。其分數的計算透過一個簡單的公式,所取用的參數包含:凝血酶原時間(prothrombin time,PT)及血清膽紅素(serum bilirubin)。其公式如下: ( 4.6 x (凝血酶原時間 - 凝血控制時間)) + 血清膽紅素 (mg/dL) 前瞻性研究顯示這一個公式能夠預測短期的預後,特別是30天內的死亡率。若其分數超過32顯示預後較差,且一個月死亡率為35 - 45%。類固醇、或己酮可可鹼(pentoxifylline)會被用於治療分數 > 32分且預後更差的患者,但其結果仍好壞參半。 若要使用國際單位制計算莫氏評分量表,如摩尔/公升(mmol/L),應將血清膽紅素(mg/dL)的值除以17。 (zh)
  • Maddrey's discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis steroid treatment. The Maddrey DF score is a predictive statistical model compares the subject's DF score with mortality prognosis within 30-day or 90-day scores. The subject's Maddrey DF score is determined by blood analysis. To calculate Maddrey discriminant function using SI units, such as micromoles per litre, divide bilirubin value by 17. (en)
  • Wskaźnik Maddreya, DF (ang. modified Maddrey's Discriminant Function) – wskaźnik rokowniczy w alkoholowym zapaleniu wątroby, opisany przez Maddreya i Boitnotta . Nadmierne spożywanie alkoholu prowadzi do alkoholowego zapalenia wątroby, marskości wątroby, a w konsekwencji do niewydolności tego narządu. Wzór na obliczanie wskaźnika:DF = ( PT [s] – prawidłowy PT [s] ) x 4,6 + bilirubina [mg/dl]. lub DF = ( PT [s] – prawidłowy PT [s] ) x 4,6 + bilirubina [μmol/l] / 17 gdzie: * DF – wskaźnik rokowniczy (czynnik dyskryminujący) * PT – czas protrombinowy * bilirubina – stężenie bilirubiny (pl)
rdfs:label
  • Índice de Maddrey (es)
  • Modified Maddrey's discriminant function (en)
  • Wskaźnik Maddreya (pl)
  • 莫德瑞評分量表 (zh)
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