About: Minaprine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Minaprine (INN, USAN, BAN) (brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.

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dbo:abstract
  • مينابرين هو مثبط أكسيداز أحادي الأمين عكوس انتقائي ، استخدم مضادا للاكتئاب في فرنسا حتى عام 1996 لكنه سحب بسبب تسببه بالاختلاجات. (ar)
  • Minaprine (INN, USAN, BAN) (brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. (en)
  • La minaprine (Bantur, Cantor) est un antidépresseur qui a été utilisé en France dans le traitement de la dépression jusqu'à son retrait du marché en 1996 car il causait des convulsions.Il a été découvert par Henri Laborit qui l'appelait aussi Agr 1240. Un premier essai a eu lieu à la clinique de la Borde à Cour-Cheverny.Une étude a montré qu'il agit comme inhibiteur réversible de la monoamine oxydase chez les rats. Une autre étude a montré une diminution de l'activité de l'acétylcholine estérase dans le striatum de rats. (fr)
dbo:casNumber
  • 25905-77-5
dbo:chEMBL
  • 278819
dbo:fdaUniiCode
  • 00U7GX0NLM
dbo:kegg
  • D05039
dbo:pubchem
  • 4199
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  • N06 (en)
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  • AX07 (en)
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  • 17 (xsd:integer)
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  • 25905 (xsd:integer)
dbp:chembl
  • 278819 (xsd:integer)
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  • 4054 (xsd:integer)
dbp:eliminationHalfLife
  • -9000.0
dbp:h
  • 22 (xsd:integer)
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  • 4 (xsd:integer)
dbp:kegg
  • D05039 (en)
dbp:legalStatus
  • Rx-only (en)
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  • 1 (xsd:integer)
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  • 4199 (xsd:integer)
dbp:routesOfAdministration
  • Oral (en)
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  • CC1=CCC3=CC=CC=C3 (en)
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  • 0 (xsd:integer)
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  • changed (en)
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  • مينابرين هو مثبط أكسيداز أحادي الأمين عكوس انتقائي ، استخدم مضادا للاكتئاب في فرنسا حتى عام 1996 لكنه سحب بسبب تسببه بالاختلاجات. (ar)
  • Minaprine (INN, USAN, BAN) (brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. (en)
  • La minaprine (Bantur, Cantor) est un antidépresseur qui a été utilisé en France dans le traitement de la dépression jusqu'à son retrait du marché en 1996 car il causait des convulsions.Il a été découvert par Henri Laborit qui l'appelait aussi Agr 1240. Un premier essai a eu lieu à la clinique de la Borde à Cour-Cheverny.Une étude a montré qu'il agit comme inhibiteur réversible de la monoamine oxydase chez les rats. Une autre étude a montré une diminution de l'activité de l'acétylcholine estérase dans le striatum de rats. (fr)
rdfs:label
  • مينابرين (ar)
  • Minaprine (fr)
  • Minaprine (en)
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