About: Metaraminol

Property	Value
dbo:abstract	Metaraminol (Handelsnamen Aramine und Araminon) ist ein Arzneistoff aus der Gruppe der Sympathomimetika zur Behandlung von zu niedrigem Blutdruck (Hypotonie). Metaraminol ist nicht für die Behandlung einer Dauererektion (Priapismus), zugelassen, es existieren jedoch Fallberichte von erfolgreicher Anwendung.Der Wirkstoff wird zudem zur Provokation eines vermuteten Familiären Mittelmeerfiebers (FMF) angewendet. Dabei wird dem Patienten eine einmalige 10-mg-Dosis verabreicht; erfolgt während der nächsten 48 Stunden ein Anfall, ist dies ein Hinweis für das Vorliegen von FMF. (de) Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β effect. It is currently sold in its generic form by Slayback Pharma. (en) Metaraminol ou metaradrina (nomes comerciais: Aramin, Aramine, entre outros) é uma amina simpaticomimética utilizada na prevenção e tratamento da hipotensão arterial, particularmente em casos de complicações relacionadas à anestesia. Atua principalmente como agonista do receptor adrenérgico alfa 1A, exercendo menor ação agonista sobre o receptor adrenérgico beta. (pt)
dbo:alternativeName	Aramine, Metaramin, Pressonex (en)
dbo:casNumber	33402-03-8 (bitartrate) 54-49-9
dbo:chEBI	6794
dbo:chEMBL	1201319
dbo:drugbank	DB00610
dbo:fdaUniiCode	818U2PZ2EH
dbo:kegg	D08192
dbo:pubchem	5906
dbo:thumbnail	wiki-commons:Special:FilePath/Metaraminol_Structural_Formulae.png?width=300
dbo:wikiPageExternalLink	https://druginfo.nlm.nih.gov/drugportal/name/metaraminol https://druginfo.nlm.nih.gov/drugportal/name/metaraminol%20bitartrate
dbo:wikiPageID	7019609 (xsd:integer)
dbo:wikiPageLength	8478 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1118261724 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Priapism dbr:Meta-Hydroxynorephedrine dbr:Bitartrate dbr:Beta-adrenergic_agonist dbr:Intravenous_therapy dbc:Phenols dbr:Anesthesia dbr:Liver dbr:Stereoisomer dbc:Phenylethanolamines dbr:Adrenergic_receptor dbr:Agonist dbc:Alpha-1_adrenergic_receptor_agonists dbr:Alpha-adrenergic_agonist dbr:Noradrenaline dbc:Substituted_amphetamines dbr:Hypotension dbc:Beta-adrenergic_agonists dbc:Cardiac_stimulants dbr:Reflex_bradycardia dbr:Endotracheal_intubation dbr:Intravenously dbr:Vasopressor dbr:Sympathomimetic_amine dbr:Alpha_adrenergic dbr:File:Metaraminol_prefilledsyringe.jpg
dbp:atcPrefix	1.0
dbp:atcSuffix	CA09 (en)
dbp:bioavailability	n/a (en)
dbp:c	9 (xsd:integer)
dbp:casNumber	54 (xsd:integer)
dbp:casSupplemental	33402 (xsd:integer)
dbp:chebi	6794 (xsd:integer)
dbp:chembl	1201319 (xsd:integer)
dbp:chemspiderid	5695 (xsd:integer)
dbp:dailymedid	Metaraminol (en)
dbp:drugbank	DB00610 (en)
dbp:h	13 (xsd:integer)
dbp:iupacName	-3 (xsd:integer)
dbp:iupharLigand	7229 (xsd:integer)
dbp:kegg	D08192 (en)
dbp:legalAu	S4 (en)
dbp:legalUk	POM (en)
dbp:legalUs	Rx-only (en)
dbp:metabolism	dbr:Liver
dbp:n	1 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pregnancyAu	C (en)
dbp:proteinBound	~45% (en)
dbp:pubchem	5906 (xsd:integer)
dbp:routesOfAdministration	dbr:Intravenous_therapy dbr:Endotracheal_intubation
dbp:smiles	O[C@H][C@@H]C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	WXFIGDLSSYIKKV-RCOVLWMOSA-N (en)
dbp:tradename	Aramine, Metaramin, Pressonex (en)
dbp:unii	818 (xsd:integer)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	462249333 (xsd:integer)
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dcterms:subject	dbc:Phenols dbc:Phenylethanolamines dbc:Alpha-1_adrenergic_receptor_agonists dbc:Substituted_amphetamines dbc:Beta-adrenergic_agonists dbc:Cardiac_stimulants
gold:hypernym	dbr:Amine
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCardiacStimulants yago:Abstraction100002137 yago:Chemical114806838 yago:Cognition100023271 yago:Compound114818238 yago:Information105816287 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Stimulation105827684 yago:Substance100019613 yago:WikicatPhenols umbel-rc:DrugProduct
rdfs:comment	Metaraminol (Handelsnamen Aramine und Araminon) ist ein Arzneistoff aus der Gruppe der Sympathomimetika zur Behandlung von zu niedrigem Blutdruck (Hypotonie). Metaraminol ist nicht für die Behandlung einer Dauererektion (Priapismus), zugelassen, es existieren jedoch Fallberichte von erfolgreicher Anwendung.Der Wirkstoff wird zudem zur Provokation eines vermuteten Familiären Mittelmeerfiebers (FMF) angewendet. Dabei wird dem Patienten eine einmalige 10-mg-Dosis verabreicht; erfolgt während der nächsten 48 Stunden ein Anfall, ist dies ein Hinweis für das Vorliegen von FMF. (de) Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β effect. It is currently sold in its generic form by Slayback Pharma. (en) Metaraminol ou metaradrina (nomes comerciais: Aramin, Aramine, entre outros) é uma amina simpaticomimética utilizada na prevenção e tratamento da hipotensão arterial, particularmente em casos de complicações relacionadas à anestesia. Atua principalmente como agonista do receptor adrenérgico alfa 1A, exercendo menor ação agonista sobre o receptor adrenérgico beta. (pt)
rdfs:label	Metaraminol (de) Metaraminol (en) Metaraminol (pt)
owl:sameAs	freebase:Metaraminol yago-res:Metaraminol http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00610 wikidata:Metaraminol http://azb.dbpedia.org/resource/متارامینول dbpedia-cy:Metaraminol dbpedia-de:Metaraminol dbpedia-fa:Metaraminol dbpedia-pt:Metaraminol dbpedia-sh:Metaraminol dbpedia-sr:Metaraminol dbpedia-vi:Metaraminol https://global.dbpedia.org/id/3o1gn
prov:wasDerivedFrom	wikipedia-en:Metaraminol?oldid=1118261724&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Metaraminol_Structural_Formulae.png wiki-commons:Special:FilePath/Metaraminol_prefilledsyringe.jpg
foaf:isPrimaryTopicOf	wikipedia-en:Metaraminol
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is dbo:wikiPageWikiLink of	dbr:List_of_adrenergic_drugs dbr:Meta-Hydroxynorephedrine dbr:Antihypotensive_agent dbr:List_of_MeSH_codes_(D02) dbr:C9H13NO2 dbr:Ephedrine dbr:Gepefrine dbr:Adrenergic_receptor dbr:Alpha-1A_adrenergic_receptor dbr:Alpha-1_adrenergic_receptor dbr:Alpha-adrenergic_agonist dbr:Familial_Mediterranean_fever dbr:Norfenefrine dbr:Rapid_sequence_induction dbr:ATC_code_C01CA09 dbr:ATCvet_code_QC01CA09 dbr:ATC_code_C01 dbr:Icoral_B dbr:Diazepam dbr:Aramine dbr:Aramist dbr:Metaraminol_bitartrate dbr:Dihydroxyamphetamine dbr:List_of_drugs:_Met dbr:Metaradrine dbr:Metaraminol_tartrate dbr:Pressonex dbr:Pressorol
is foaf:primaryTopic of	wikipedia-en:Metaraminol