About: Mepitiostane

Property	Value
dbo:abstract	Mepitiostane, sold under the brand name Thioderon, is an orally active antiestrogen and anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which is marketed in Japan as an antineoplastic agent for the treatment of breast cancer. It is a prodrug of epitiostanol. The drug was patented and described in 1968. (en) メピチオスタン（Mepitiostane）は-17-メトキシシクロペンチルエーテル（epitiostanol 17-methyloxycyclopentyl ether）としても知られるステロイド系化合物であり、、アンドロゲン作用、アナボリックステロイド作用を持ち、日本で乳癌の化学療法に用いられるほか、腎不全で透析中の腎性貧血の治療にも応用される。商品名チオデロン。エピチオスタノールの17位をエーテル化したプロドラッグで、経口投与が可能である。 (ja)
dbo:alternativeName	Thioderon (en)
dbo:casNumber	21362-69-6
dbo:class	dbr:Androgen_ether dbr:Androgen dbr:Antiestrogen dbr:Anabolic_steroid
dbo:fdaUniiCode	O00404969K
dbo:kegg	D01602
dbo:pubchem	9909202
dbo:thumbnail	wiki-commons:Special:FilePath/Mepitiostane.svg?width=300
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dbo:wikiPageLength	10692 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1095869897 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Episulfides dbr:Methylepitiostanol dbr:Androgen_ether dbr:Breast_cancer dbr:Androgen dbr:Antiestrogen dbr:Renal_failure dbc:Androgens_and_anabolic_steroids dbc:Androstanes dbc:Antiestrogens dbc:Cyclopentanes dbc:Prodrugs dbr:Meningioma dbr:Oral_administration dbr:Epitiostanol dbr:Androstane dbr:Anemia dbr:Steroid dbc:Androgen_ethers dbr:Receptor_antagonist dbr:Prodrug dbc:Hormonal_antineoplastic_drugs dbr:Anabolic_steroid dbr:Estrogen_receptor dbr:Generic_term dbr:Hirsutism dbr:Japan dbr:Tamoxifen dbr:Acne dbr:Hepatotoxicity dbr:Dihydrotestosterone dbr:Case_report dbr:Side_effect dbr:Voice_change dbr:Ether dbr:Antineoplastic_agent dbr:Anabolic–androgenic_steroid dbr:Synthetic_compound dbr:Chemical_derivative dbr:Virilizing
dbp:atcPrefix	None (en)
dbp:c	25 (xsd:integer)
dbp:casNumber	21362 (xsd:integer)
dbp:chemspiderid	8084854 (xsd:integer)
dbp:class	dbr:Androgen_ether dbr:Androgen dbr:Antiestrogen dbr:Anabolic_steroid
dbp:h	40 (xsd:integer)
dbp:iupacName	-15 (xsd:integer)
dbp:kegg	D01602 (en)
dbp:legalStatus	Rx-only (en)
dbp:o	2 (xsd:integer)
dbp:pubchem	9909202 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:s	1 (xsd:integer)
dbp:smiles	C[C@]12CC[C@H]3[C@H]CC[C@@H]5[C@@]3C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	IVDYZAAPOLNZKG-KWHRADDSSA-N (en)
dbp:synonyms	10364 (xsd:integer)
dbp:tradename	Thioderon (en)
dbp:unii	O00404969K (en)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	450845964 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:width	250 (xsd:integer)
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dcterms:subject	dbc:Episulfides dbc:Androgens_and_anabolic_steroids dbc:Androstanes dbc:Antiestrogens dbc:Cyclopentanes dbc:Prodrugs dbc:Androgen_ethers dbc:Hormonal_antineoplastic_drugs
gold:hypernym	dbr:Steroid
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAnabolicSteroids yago:WikicatAndrogens yago:Abstraction100002137 yago:AnabolicSteroid115111116 yago:Androgen114747587 yago:BodySubstance105263850 yago:Hormone105407119 yago:LiquidBodySubstance105397468 yago:Matter100020827 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Secretion105404728 yago:SteroidHormone114745635 yago:Substance100019613 umbel-rc:DrugProduct
rdfs:comment	Mepitiostane, sold under the brand name Thioderon, is an orally active antiestrogen and anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which is marketed in Japan as an antineoplastic agent for the treatment of breast cancer. It is a prodrug of epitiostanol. The drug was patented and described in 1968. (en) メピチオスタン（Mepitiostane）は-17-メトキシシクロペンチルエーテル（epitiostanol 17-methyloxycyclopentyl ether）としても知られるステロイド系化合物であり、、アンドロゲン作用、アナボリックステロイド作用を持ち、日本で乳癌の化学療法に用いられるほか、腎不全で透析中の腎性貧血の治療にも応用される。商品名チオデロン。エピチオスタノールの17位をエーテル化したプロドラッグで、経口投与が可能である。 (ja)
rdfs:label	メピチオスタン (ja) Mepitiostane (en)
rdfs:seeAlso	dbr:Anabolic_steroids dbr:Anabolic_steroid dbr:List_of_androgens
owl:sameAs	freebase:Mepitiostane yago-res:Mepitiostane wikidata:Mepitiostane dbpedia-fa:Mepitiostane dbpedia-ja:Mepitiostane dbpedia-sh:Mepitiostane dbpedia-sr:Mepitiostane dbpedia-vi:Mepitiostane https://global.dbpedia.org/id/4sCwA
prov:wasDerivedFrom	wikipedia-en:Mepitiostane?oldid=1095869897&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Mepitiostane.svg
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is foaf:primaryTopic of	wikipedia-en:Mepitiostane