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- Die Myosin-Leichte-Ketten-Phosphatase (auch MLCP oder Myosin-Light-Chain-Phosphatase) ist ein Enzym, welches in den Zellen der glatten Muskulatur vorkommt. Sie dephosphoryliert die regulatorische leichte Kette des Myosins. Dies führt normalerweise zu einer Relaxation der glatten Muskulatur. MLCP ist ein Dimer aus der katalytischen Untereinheit PPP1CB (EC 3.1.3.53) und der regulatorischen Untereinheit (eine von PPP1R12A/B/C), die das Substrat bestimmt. Bindung von PPP1CB an andere Untereinheiten führt zu anderen Substrat-Spezifitäten. MLCP wirkt antagonistisch zum Enzym der Myosin-Leichte-Ketten-Kinase. Die katalysierte Reaktion lautet: [Myosin-Leichte-Kette]-Phosphat + H2O [Myosin-Leichte-Kette] + PPi (de)
- Myosin light-chain phosphatase, also called myosin phosphatase (EC 3.1.3.53; systematic name [myosin-light-chain]-phosphate phosphohydrolase), is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II: [myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate This dephosphorylation reaction occurs in smooth muscle tissue and initiates the relaxation process of the muscle cells. Thus, myosin phosphatase undoes the muscle contraction process initiated by myosin light-chain kinase. The enzyme is composed of three subunits: the catalytic region (protein phosphatase 1, or PP1), the myosin binding subunit (MYPT1), and a third subunit (M20) of unknown function. The catalytic region uses two manganese ions as catalysts to dephosphorylate the light-chains on myosin, which causes a conformational change in the myosin and relaxes the muscle. The enzyme is highly conserved and is found in all organisms’ smooth muscle tissue. While it is known that myosin phosphatase is regulated by rho-associated protein kinases, there is current debate about whether other molecules, such as arachidonic acid and cAMP, also regulate the enzyme. (en)
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- 14056 (xsd:nonNegativeInteger)
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- Structure of complex between PP1 and a portion of MYPT1, generated from 1s70 (en)
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- Myosin Light-Chain Phosphatase (en)
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- Die Myosin-Leichte-Ketten-Phosphatase (auch MLCP oder Myosin-Light-Chain-Phosphatase) ist ein Enzym, welches in den Zellen der glatten Muskulatur vorkommt. Sie dephosphoryliert die regulatorische leichte Kette des Myosins. Dies führt normalerweise zu einer Relaxation der glatten Muskulatur. MLCP ist ein Dimer aus der katalytischen Untereinheit PPP1CB (EC 3.1.3.53) und der regulatorischen Untereinheit (eine von PPP1R12A/B/C), die das Substrat bestimmt. Bindung von PPP1CB an andere Untereinheiten führt zu anderen Substrat-Spezifitäten. Die katalysierte Reaktion lautet: (de)
- Myosin light-chain phosphatase, also called myosin phosphatase (EC 3.1.3.53; systematic name [myosin-light-chain]-phosphate phosphohydrolase), is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II: [myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate (en)
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- Myosin-Leichte-Ketten-Phosphatase (de)
- Myosin-light-chain phosphatase (en)
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- Myosin Light-Chain Phosphatase (en)
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