About: MIRN21

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microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop precursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21.

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dbo:abstract
  • microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop precursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21. (en)
  • Le micro-ARN 21 (miR-21) est un micro-ARN impliqué dans de très nombreux processus physiologiques et pathologiques et le sujet d'une importante littérature scientifique.Il est notamment connu pour son implication dans le glioblastome, une forme agressive de cancer du cerveau, le fonctionnement cardiaque et la fibrose tissulaire. (fr)
  • マイクロRNA-21(=miR-21、has-mir-21、miRNA21)(*以下、miR-21と表記)とは、MIR21遺伝子によってコードされている哺乳類のマイクロRNAである。miR-21は哺乳類におけるマイクロRNAでもごく初期に同定されたマイクロRNAのうちのひとつである。成熟miR-21の配列は進化の過程で強く保存されている。ヒトmiR-21遺伝子は液胞膜タンパクと呼ばれるTMEM49遺伝子によって、第17番染色体長腕(17q23.2)の正鎖に存在している。miR-21はコード遺伝子の転写方向におけるイントロン領域に存在している。にもかかわらず、自身のプロモーター領域を有しており、pri-miR-21と呼ばれる約3400塩基の独自の初期転写産物を生成する。ステムループ構造を有する前駆体miR-21(pre-miR-21)はpri-miR-21の2445~2516番の塩基に存在している。 (ja)
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  • RF00658 (en)
dbp:name
  • mir-21 microRNA precursor family (en)
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  • microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop precursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21. (en)
  • Le micro-ARN 21 (miR-21) est un micro-ARN impliqué dans de très nombreux processus physiologiques et pathologiques et le sujet d'une importante littérature scientifique.Il est notamment connu pour son implication dans le glioblastome, une forme agressive de cancer du cerveau, le fonctionnement cardiaque et la fibrose tissulaire. (fr)
  • マイクロRNA-21(=miR-21、has-mir-21、miRNA21)(*以下、miR-21と表記)とは、MIR21遺伝子によってコードされている哺乳類のマイクロRNAである。miR-21は哺乳類におけるマイクロRNAでもごく初期に同定されたマイクロRNAのうちのひとつである。成熟miR-21の配列は進化の過程で強く保存されている。ヒトmiR-21遺伝子は液胞膜タンパクと呼ばれるTMEM49遺伝子によって、第17番染色体長腕(17q23.2)の正鎖に存在している。miR-21はコード遺伝子の転写方向におけるイントロン領域に存在している。にもかかわらず、自身のプロモーター領域を有しており、pri-miR-21と呼ばれる約3400塩基の独自の初期転写産物を生成する。ステムループ構造を有する前駆体miR-21(pre-miR-21)はpri-miR-21の2445~2516番の塩基に存在している。 (ja)
rdfs:label
  • Micro-ARN 21 (fr)
  • MIRN21 (en)
  • MiRNA-21 (ja)
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