About: Lumicitabine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Lumicitabine (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It acts as an RNA polymerase inhibitor. While it showed promise in early clinical trials, poor results in Phase IIb trials led to it being discontinued from development for treatment of RSV. Research continues to determine whether it may be useful for the treatment of diseases caused by other RNA viruses, and it has been found to show activity against Nipah virus.

Property	Value
dbo:abstract	Lumicitabine (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It acts as an RNA polymerase inhibitor. While it showed promise in early clinical trials, poor results in Phase IIb trials led to it being discontinued from development for treatment of RSV. Research continues to determine whether it may be useful for the treatment of diseases caused by other RNA viruses, and it has been found to show activity against Nipah virus. (en)
dbo:alternativeName	Lumicitabine (en)
dbo:casNumber	1445385-02-3
dbo:fdaUniiCode	BNW5PQ52G1
dbo:pubchem	89658382
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dbp:iupacName	[-5--2--4-fluoro-3-oxolan-2-yl]methyl 2-methylpropanoate (en)
dbp:legalUs	Investigational New Drug (en)
dbp:molecularWeight	433.900000 (xsd:double)
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dbp:pubchem	89658382 (xsd:integer)
dbp:smiles	CCCOC[C@@]1CCl (en)
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dbp:stdinchikey	MJVKYGMNSQJLIN-KYZVSKTDSA-N (en)
dbp:tradename	Lumicitabine (en)
dbp:unii	BNW5PQ52G1 (en)
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rdfs:comment	Lumicitabine (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It acts as an RNA polymerase inhibitor. While it showed promise in early clinical trials, poor results in Phase IIb trials led to it being discontinued from development for treatment of RSV. Research continues to determine whether it may be useful for the treatment of diseases caused by other RNA viruses, and it has been found to show activity against Nipah virus. (en)
rdfs:label	Lumicitabine (en)
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