About: Lortalamine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s. It acts as a potent and highly selective norepinephrine reuptake inhibitor. Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals. It has been used to label the norepinephrine transporter in positron emission tomography studies.

Property Value
dbo:abstract
  • Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s. It acts as a potent and highly selective norepinephrine reuptake inhibitor. Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals. It has been used to label the norepinephrine transporter in positron emission tomography studies. (en)
  • A lortalamina (LM-1404) é um antidepressivo que foi sintetizado no início dos anos 80. Atua como um inibidor potente e altamente seletivo da recaptação de noradrenalina. A lortalamina estava em desenvolvimento para uso clínico, mas foi deixada de lado, possivelmente devido à descoberta de que produzia toxicidade ocular em animais. Tem sido utilizada para sinalizar o transportador de noradrenalina em estudos de tomografia por emissão de pósitrons. (pt)
dbo:casNumber
  • 70384-91-7
dbo:fdaUniiCode
  • 9GIR4SV22T
dbo:kegg
  • D04781
dbo:pubchem
  • 51047
dbo:thumbnail
dbo:wikiPageID
  • 28850355 (xsd:integer)
dbo:wikiPageLength
  • 4787 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1006340689 (xsd:integer)
dbo:wikiPageWikiLink
dbp:atcPrefix
  • None (en)
dbp:c
  • 15 (xsd:integer)
dbp:casNumber
  • 70384 (xsd:integer)
dbp:chemspiderid
  • 16736803 (xsd:integer)
dbp:cl
  • 1 (xsd:integer)
dbp:eliminationHalfLife
  • 18000.0
dbp:excretion
dbp:h
  • 17 (xsd:integer)
dbp:image
  • Lortalamine ball-and-stick model.png (en)
dbp:iupacName
  • 8 (xsd:integer)
dbp:kegg
  • D04781 (en)
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 2 (xsd:integer)
dbp:pubchem
  • 51047 (xsd:integer)
dbp:routesOfAdministration
dbp:smiles
  • Clc1ccc2O[C@]34NCC[C@@H][C@H]4CNCC3 (en)
dbp:unii
  • 9 (xsd:integer)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s. It acts as a potent and highly selective norepinephrine reuptake inhibitor. Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals. It has been used to label the norepinephrine transporter in positron emission tomography studies. (en)
  • A lortalamina (LM-1404) é um antidepressivo que foi sintetizado no início dos anos 80. Atua como um inibidor potente e altamente seletivo da recaptação de noradrenalina. A lortalamina estava em desenvolvimento para uso clínico, mas foi deixada de lado, possivelmente devido à descoberta de que produzia toxicidade ocular em animais. Tem sido utilizada para sinalizar o transportador de noradrenalina em estudos de tomografia por emissão de pósitrons. (pt)
rdfs:label
  • Lortalamine (en)
  • Lortalamina (pt)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License