John Sibley (1757–1837) was an American surgeon. After serving as a surgeon's assistant in the American Revolutionary War, he moved to Natchitoches, Louisiana to work as a contract surgeon. From 1805 to 1815, Sibley was also the official Indian Agent of New Orleans Territory. Later in life, he served as a Senator in the Louisiana State Senate, as well as a colonel of a militia, a cattle farmer, a cotton planter, and a salt manufacturer.