About: JWH-200

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JWH-200 (WIN 55,225) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favourable pharmacokinetic characteristics. It was discovered in 1991 by Sterling Drug as a potential analgesic following the earlier identification of related compounds such as pravadoline and WIN 55,212-2.

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dbo:abstract
  • JWH-200 (WIN 55,225) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favourable pharmacokinetic characteristics. It was discovered in 1991 by Sterling Drug as a potential analgesic following the earlier identification of related compounds such as pravadoline and WIN 55,212-2. (en)
  • JWH-200 – organiczny związek chemiczny, syntetyczny kanabinoid otrzymany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2010 roku jest w grupie I-N Ustawy o przeciwdziałaniu narkomanii. (pl)
  • JWH-200 (WIN 55,225) — органическое химическое соединение. Анальгетик, действует как возбудитель рецепторов. (ru)
dbo:casNumber
  • 103610-04-4
dbo:fdaUniiCode
  • 9HN5J913P3
dbo:pubchem
  • 10045570
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  • 25 (xsd:integer)
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  • 103610 (xsd:integer)
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  • 8221134 (xsd:integer)
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  • 24 (xsd:integer)
dbp:iupacName
  • -naphthalen-1-ylmethanone (en)
dbp:legalAu
  • S9 (en)
dbp:legalCa
  • Schedule II (en)
dbp:legalDe
  • Anlage II (en)
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  • Class B (en)
dbp:legalUs
  • Schedule I (en)
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  • 2 (xsd:integer)
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  • 2 (xsd:integer)
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  • O=CC3=CNCCN5CCOCC5 (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • SZWYXJHTNGJPKU-UHFFFAOYSA-N (en)
dbp:synonyms
  • WIN 55,225 (en)
dbp:unii
  • 9 (xsd:integer)
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  • 436337708 (xsd:integer)
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  • changed (en)
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rdfs:comment
  • JWH-200 (WIN 55,225) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC, but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favourable pharmacokinetic characteristics. It was discovered in 1991 by Sterling Drug as a potential analgesic following the earlier identification of related compounds such as pravadoline and WIN 55,212-2. (en)
  • JWH-200 – organiczny związek chemiczny, syntetyczny kanabinoid otrzymany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2010 roku jest w grupie I-N Ustawy o przeciwdziałaniu narkomanii. (pl)
  • JWH-200 (WIN 55,225) — органическое химическое соединение. Анальгетик, действует как возбудитель рецепторов. (ru)
rdfs:label
  • JWH-200 (en)
  • JWH-200 (pl)
  • JWH-200 (ru)
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