Musumba Isaac Isanga is a Ugandan lawyer and politician. He served as the State Minister for Regional Foreign Affairs, from June 2006 until May 2011. In the cabinet reshuffle on 27 May 2011, he was dropped from the cabinet and was replaced by Asuman Kiyingi. He also served as the elected Member of Parliament (MP), representing "Buzaaya County", Kamuli District, from 1996 until 2011. During the 2011 national elections, he lost to Muzaale Martin Kisule Mugabi, during the National Resistance Movement (NRM) primaries. In 2016, he bounced back into the 10th parliament (2016 - 2021), representing Buzaaya County, in Kamuli District, on the NRM ticket. In the 2021 elections, he lost in the NRM primaries to Martin Muzaale and decided to contest as an Independent candidate and further lost to the NR