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- The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB). These receptors are generally found on human neutrophils, a type of white blood cell of the myeloid lineage, with approximately 65,000 receptors per neutrophil. Both receptors have a size of 60kDa, are glycosylated (contains covalent attachments and modifications) and G-protein linked, and can cause an increase in intracellular Ca2+ levels. Binding of Interleukin 8 leads to activation of the cell (commonly a neutrophil), allowing it to recruit more white blood cells to the site of Interleukin 8 release and to produce enzymes that would assist in the destruction of foreign material at the site of infection (en)
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- IL8RA
- IL8RB
- CMKAR1, CXCR1, CKR-1, CDw128a, CD181
- CXCR2, CKR-2, CDw128b
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- 8344 (xsd:nonNegativeInteger)
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- CMKAR1, CXCR1, CKR-1, CDw128a, CD181 (en)
- CXCR2, CKR-2, CDw128b (en)
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| rdfs:comment
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- The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB). These receptors are generally found on human neutrophils, a type of white blood cell of the myeloid lineage, with approximately 65,000 receptors per neutrophil. Both receptors have a size of 60kDa, are glycosylated (contains covalent attachments and modifications) and G-protein linked, and can cause an increase in intracellular Ca2+ levels. Binding of Interleukin 8 leads to activation of the cell (commonly a neutrophil), allowing it to recruit more white blood cells to the site of Interleukin 8 release and to produce enzymes that would assist in the destruction of foreign material at the site of infection (en)
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| rdfs:label
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- Interleukin-8 receptor (en)
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- Interleukin-8 Receptor, alpha (en)
- Interleukin-8 Receptor, beta (en)
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