About: Idoxifene

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Idoxifene (INN, USAN, BAN) (former developmental code names CB-7432, SB-223030), also known as pyrrolidino-4-iodotamoxifen, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group which was under development for the treatment of breast cancer and postmenopausal osteoporosis but was never marketed. It reached phase III clinical trials for postmenopausal osteoporosis and phase II clinical trials for breast cancer before development was discontinued in 1999 due to insufficient effectiveness in both cases.

Property	Value
dbo:abstract	Idoxifene (INN, USAN, BAN) (former developmental code names CB-7432, SB-223030), also known as pyrrolidino-4-iodotamoxifen, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group which was under development for the treatment of breast cancer and postmenopausal osteoporosis but was never marketed. It reached phase III clinical trials for postmenopausal osteoporosis and phase II clinical trials for breast cancer before development was discontinued in 1999 due to insufficient effectiveness in both cases. (en)
dbo:casNumber	116057-75-1
dbo:chEMBL	6318
dbo:fdaUniiCode	456UXE9867
dbo:kegg	D04496
dbo:pubchem	3034011
dbo:thumbnail	wiki-commons:Special:FilePath/Idoxifene.svg?width=300
dbo:wikiPageExternalLink	http://adisinsight.springer.com/drugs/800003448
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dbo:wikiPageWikiLink	dbr:Breast_cancer dbr:Menopause dbc:Abandoned_drugs dbc:Iodoarenes dbc:Phenol_ethers dbc:Pyrrolidines dbr:Chemical_synthesis dbr:Oral_administration dbr:Clinical_trial dbc:Hormonal_antineoplastic_drugs dbr:Triphenylethylene dbc:Triphenylethylenes dbr:British_Approved_Name dbr:Nonsteroidal dbr:Osteoporosis dbc:Selective_estrogen_receptor_modulators dbr:International_Nonproprietary_Name dbr:Effectiveness dbr:Selective_estrogen_receptor_modulator dbr:United_States_Adopted_Name dbr:Phases_of_clinical_research
dbp:c	28 (xsd:integer)
dbp:casNumber	116057 (xsd:integer)
dbp:chembl	6318 (xsd:integer)
dbp:chemspiderid	2298565 (xsd:integer)
dbp:eliminationHalfLife	54000.0 1987200.0
dbp:h	30 (xsd:integer)
dbp:i	1 (xsd:integer)
dbp:iupacName	1 (xsd:integer)
dbp:kegg	D04496 (en)
dbp:n	1 (xsd:integer)
dbp:o	1 (xsd:integer)
dbp:pubchem	3034011 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:smiles	CC/C/C4=CC=CC=C4 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	JJKOTMDDZAJTGQ-DQSJHHFOSA-N (en)
dbp:synonyms	CB-7432, SB-223030; Pyrrolidino-4-iodotamoxifen; 4-Iodopyrrolidinotamoxifen (en)
dbp:unii	456 (xsd:integer)
dbp:width	250 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Antineoplastic-drug-stub dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Genito-urinary-drug-stub dbt:Reflist dbt:Short_description dbt:Fdacite
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gold:hypernym	dbr:Antagonist
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Element114840755 yago:Matter100020827 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatPhenolEthers
rdfs:comment	Idoxifene (INN, USAN, BAN) (former developmental code names CB-7432, SB-223030), also known as pyrrolidino-4-iodotamoxifen, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group which was under development for the treatment of breast cancer and postmenopausal osteoporosis but was never marketed. It reached phase III clinical trials for postmenopausal osteoporosis and phase II clinical trials for breast cancer before development was discontinued in 1999 due to insufficient effectiveness in both cases. (en)
rdfs:label	Idoxifene (en)
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prov:wasDerivedFrom	wikipedia-en:Idoxifene?oldid=1017714090&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Idoxifene.svg
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is dbo:wikiPageWikiLink of	dbr:Index_of_oncology_articles dbr:List_of_selective_estrogen_receptor_modulators dbr:Triphenylethylene dbr:Nonsteroidal dbr:List_of_drugs:_Ia–Il
is foaf:primaryTopic of	wikipedia-en:Idoxifene