About: Ibutilide

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.

Property Value
dbo:abstract
  • إيبوتيليد (بالإنجليزية: Ibutilide)‏ هو دواء يُستعمل في علاج: * رجفان أذيني (ar)
  • Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents. Ibutilide is marketed as Corvert by Pfizer. Administration resulted in successful heart rhythm control in 31-44% of patients within 90 minutes, with sustained polymorphic ventricular tachycardia in 0.9-2.5% of patients. It appears to show better results in atrial flutter as compared to atrial fibrillation. (en)
  • La ibutilide è un farmaco anti-aritmico di classe III utilizzato prevalentemente nei casi di fibrillazione atriale e flutter atriale; in quest'ultimo caso, trova un importante impiego specifico. (it)
dbo:alternativeName
  • Corvert (en)
dbo:casNumber
  • 122647-31-8
dbo:chEMBL
  • 533
dbo:drugbank
  • DB00308
dbo:fdaUniiCode
  • 2436VX1U9B
dbo:kegg
  • D00648
dbo:medlinePlus
  • a601248
dbo:pubchem
  • 60753
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  • 1.0
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  • BD05 (en)
dbp:bioavailability
  • N/A (en)
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  • 20 (xsd:integer)
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  • 122647 (xsd:integer)
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  • 533 (xsd:integer)
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dbp:drugbank
  • DB00308 (en)
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  • 21600.0
dbp:excretion
  • Renal , fecal (en)
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  • 36 (xsd:integer)
dbp:iupacName
  • N-methanesulfonamide (en)
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  • 7200 (xsd:integer)
dbp:kegg
  • D00648 (en)
dbp:medlineplus
  • a601248 (en)
dbp:metabolism
  • Hepatic oxidation (en)
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  • 2 (xsd:integer)
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  • 3 (xsd:integer)
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  • C (en)
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  • 40.0
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  • Intravenous (en)
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  • 1 (xsd:integer)
dbp:smiles
  • O=SC (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • ALOBUEHUHMBRLE-UHFFFAOYSA-N (en)
dbp:tradename
  • Corvert (en)
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  • 2436 (xsd:integer)
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  • إيبوتيليد (بالإنجليزية: Ibutilide)‏ هو دواء يُستعمل في علاج: * رجفان أذيني (ar)
  • La ibutilide è un farmaco anti-aritmico di classe III utilizzato prevalentemente nei casi di fibrillazione atriale e flutter atriale; in quest'ultimo caso, trova un importante impiego specifico. (it)
  • Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents. (en)
rdfs:label
  • إيبوتيليد (ar)
  • Ibutilide (en)
  • Ibutilide (it)
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