About: IPTBO

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice. IPTBO is found among a group of highly toxic bicyclic phosphates. Generally, bicyclic phosphates disrupt chloride ion flow through GABA receptors, causing CNS overstimulation and lethal convulsions within minutes. IPTBO has these effects when injected, inhaled, or ingested and is one of the more toxic types of this antagonist.

Property	Value
dbo:abstract	IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice. IPTBO is found among a group of highly toxic bicyclic phosphates. Generally, bicyclic phosphates disrupt chloride ion flow through GABA receptors, causing CNS overstimulation and lethal convulsions within minutes. IPTBO has these effects when injected, inhaled, or ingested and is one of the more toxic types of this antagonist. (en)
dbo:alternativeName	4-Isopropylbicyclophosphate (en)
dbo:iupacName	4-(Propan-2-yl)-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octan-1-one (en)
dbo:thumbnail	wiki-commons:Special:FilePath/Isopropylbicyclophosphate.svg?width=300
dbo:wikiPageID	57057218 (xsd:integer)
dbo:wikiPageLength	11926 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1101915115 (xsd:integer)
dbo:wikiPageWikiLink	dbc:GABAA_receptor_negative_allosteric_modulators dbc:Isopropyl_compounds dbc:Oxygen_heterocycles dbr:Convulsant dbr:Convulsion dbr:Organophosphate_poisoning dbr:GABAA_receptor dbr:GABA_receptor_antagonist dbr:Acetylcholinesterase dbr:Adenosine_triphosphate dbr:Cyclic_adenosine_monophosphate dbr:Cyclic_guanosine_monophosphate dbr:EBOB dbr:Central_nervous_system dbc:Convulsants dbc:Neurotoxins dbr:Guanosine_triphosphate dbr:Aerotoxic_syndrome dbr:Bicyclic_phosphate dbc:Bicyclic_phosphates dbr:TBPO dbr:TBPS dbr:Diisopropyl_fluorophosphate dbr:Neopentylene_fluorophosphate dbr:File:SynthesisIPTBO.jpg
dbp:imagefile	IPTBO_3D_structure.png (en) Isopropylbicyclophosphate.svg (en)
dbp:imagesize	120 (xsd:integer)
dbp:name	IPTBO (en)
dbp:othernames	4 (xsd:integer)
dbp:pin	4 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:GABA_receptor_modulators dbt:Reflist dbt:Convulsants dbt:Neurotoxins
dcterms:subject	dbc:GABAA_receptor_negative_allosteric_modulators dbc:Isopropyl_compounds dbc:Oxygen_heterocycles dbc:Convulsants dbc:Neurotoxins dbc:Bicyclic_phosphates
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound
rdfs:comment	IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice. IPTBO is found among a group of highly toxic bicyclic phosphates. Generally, bicyclic phosphates disrupt chloride ion flow through GABA receptors, causing CNS overstimulation and lethal convulsions within minutes. IPTBO has these effects when injected, inhaled, or ingested and is one of the more toxic types of this antagonist. (en)
rdfs:label	IPTBO (en)
owl:sameAs	wikidata:IPTBO https://global.dbpedia.org/id/94ttF
prov:wasDerivedFrom	wikipedia-en:IPTBO?oldid=1101915115&ns=0
foaf:depiction	wiki-commons:Special:FilePath/IPTBO_3D_structure.png wiki-commons:Special:FilePath/Isopropylbicyclophosphate.svg wiki-commons:Special:FilePath/SynthesisIPTBO.jpg
foaf:isPrimaryTopicOf	wikipedia-en:IPTBO
foaf:name	IPTBO (en)
is dbo:wikiPageWikiLink of	dbr:Convulsant dbr:BIDN dbr:EBOB dbr:Bicyclic_phosphate dbr:TBPO dbr:TBPS dbr:Neopentylene_fluorophosphate
is foaf:primaryTopic of	wikipedia-en:IPTBO