About: IDX-184

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

IDX-184 is an antiviral drug which was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor. While it showed reasonable effectiveness in early clinical trials it did not progress past Phase IIb. However research using this drug has continued as it shows potentially useful activity against other emerging viral diseases such as Zika virus, and coronaviruses including MERS, and SARS-CoV-2.

Property Value
dbo:abstract
  • IDX-184 is an antiviral drug which was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor. While it showed reasonable effectiveness in early clinical trials it did not progress past Phase IIb. However research using this drug has continued as it shows potentially useful activity against other emerging viral diseases such as Zika virus, and coronaviruses including MERS, and SARS-CoV-2. (en)
  • IDX-184是一种抗病毒药物,开发用作 RNA聚合酶抑制剂来治疗丙型肝炎。尽管它在早期臨床試驗中显示出一定效果,但并未通过IIb期试验。然而,该药物的研究仍在继续,并对一些新病毒(如茲卡病毒、MERS和SARS-CoV-2等冠状病毒)显示出一定的药物活性。 (zh)
dbo:casNumber
  • 1036915-08-8
dbo:chEMBL
  • 3793161
dbo:fdaUniiCode
  • 4W44B4S9OC
dbo:pubchem
  • 135565589
dbo:thumbnail
dbo:wikiPageID
  • 63551128 (xsd:integer)
dbo:wikiPageLength
  • 4397 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1123461137 (xsd:integer)
dbo:wikiPageWikiLink
dbp:c
  • 25 (xsd:integer)
dbp:casNumber
  • 1036915 (xsd:integer)
dbp:chembl
  • 3793161 (xsd:integer)
dbp:chemspiderid
  • 34066446 (xsd:integer)
dbp:h
  • 35 (xsd:integer)
dbp:iupacName
  • S-[2-{[-5--3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-phosphoryl}oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate (en)
dbp:legalUs
  • Investigational drug (en)
dbp:molecularWeight
  • 626.600000 (xsd:double)
dbp:n
  • 6 (xsd:integer)
dbp:o
  • 9 (xsd:integer)
dbp:p
  • 1 (xsd:integer)
dbp:pubchem
  • 135565589 (xsd:integer)
dbp:s
  • 1 (xsd:integer)
dbp:smiles
  • C[C@]1O (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • FGHMGRXAHIXTBM-TWFJNEQDSA-N (en)
dbp:unii
  • 4 (xsd:integer)
dbp:width
  • 260 (xsd:integer)
dbp:wikiPageUsesTemplate
dcterms:subject
rdf:type
rdfs:comment
  • IDX-184 is an antiviral drug which was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor. While it showed reasonable effectiveness in early clinical trials it did not progress past Phase IIb. However research using this drug has continued as it shows potentially useful activity against other emerging viral diseases such as Zika virus, and coronaviruses including MERS, and SARS-CoV-2. (en)
  • IDX-184是一种抗病毒药物,开发用作 RNA聚合酶抑制剂来治疗丙型肝炎。尽管它在早期臨床試驗中显示出一定效果,但并未通过IIb期试验。然而,该药物的研究仍在继续,并对一些新病毒(如茲卡病毒、MERS和SARS-CoV-2等冠状病毒)显示出一定的药物活性。 (zh)
rdfs:label
  • IDX-184 (en)
  • IDX-184 (zh)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License