About: Hypotonic-hyporesponsive episode

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A hypotonic-hyporesponsive episode (HHE) is defined as sudden onset of poor muscle tone, , and pale or bluish skin occurring within 48 hours after vaccination, most commonly pertussis vaccination. An HHE is estimated to occur after 1 in 4,762 to 1 in 1,408 doses of whole cell pertussis vaccine, and after 1 in 14,286 to 1 in 2,778 doses of acellular pertussis vaccine.

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dbo:abstract
  • A hypotonic-hyporesponsive episode (HHE) is defined as sudden onset of poor muscle tone, , and pale or bluish skin occurring within 48 hours after vaccination, most commonly pertussis vaccination. An HHE is estimated to occur after 1 in 4,762 to 1 in 1,408 doses of whole cell pertussis vaccine, and after 1 in 14,286 to 1 in 2,778 doses of acellular pertussis vaccine. (en)
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  • 56378847 (xsd:integer)
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  • 3328 (xsd:nonNegativeInteger)
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  • 1078066040 (xsd:integer)
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dbp:causes
  • Vaccination, most commonly pertussis vaccine. (en)
dbp:deaths
  • None reported (en)
dbp:diagnosis
  • Based on symptoms. (en)
dbp:differential
  • Vasovagal syncope, seizure (en)
dbp:duration
  • 1209660.0
dbp:name
  • Hypotonic-hyporesponsive episode (en)
dbp:onset
  • 172860.0
dbp:prevention
  • Those who experience an HHE after pertussis vaccination may avoid further pertussis vaccines. (en)
dbp:symptoms
  • Hypotonia, hyporesponsiveness, pallor, cyanosis. (en)
dbp:treatment
  • Usually resolves on its own, management involves checking the airway, breathing, and circulation, and hospitalization for observation and to rule out other conditions. (en)
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  • A hypotonic-hyporesponsive episode (HHE) is defined as sudden onset of poor muscle tone, , and pale or bluish skin occurring within 48 hours after vaccination, most commonly pertussis vaccination. An HHE is estimated to occur after 1 in 4,762 to 1 in 1,408 doses of whole cell pertussis vaccine, and after 1 in 14,286 to 1 in 2,778 doses of acellular pertussis vaccine. (en)
rdfs:label
  • Hypotonic-hyporesponsive episode (en)
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foaf:name
  • Hypotonic-hyporesponsive episode (HHE) (en)
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