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- Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates. It is enabled by techniques for hyperpolarization of carbon-13-containing molecules using dynamic nuclear polarization and rapid dissolution to create an injectable solution. Following the injection of a hyperpolarized substrate, metabolic activity can be mapped based on enzymatic conversion of the injected molecule. In contrast with other metabolic imaging methods such as positron emission tomography, hyperpolarized carbon-13 MRI provides chemical as well as spatial information, allowing this technique to be used to probe the activity of specific metabolic pathways. This has led to new ways of imaging disease. For example, metabolic conversion of hyperpolarized pyruvate into lactate is increasingly being used to image cancerous tissues via the Warburg effect. (en)
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- Hyperpolarized carbon-13 MRI (en)
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- imaging technique for probing perfusion and metabolism (en)
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- Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates. It is enabled by techniques for hyperpolarization of carbon-13-containing molecules using dynamic nuclear polarization and rapid dissolution to create an injectable solution. Following the injection of a hyperpolarized substrate, metabolic activity can be mapped based on enzymatic conversion of the injected molecule. In contrast with other metabolic imaging methods such as positron emission tomography, hyperpolarized carbon-13 MRI provides chemical as well as spatial information, allowing this technique to be used to probe the activity of specific metabolic pathways. This has led to new ways of imaging disease. For example, metabolic conversion of hyperpola (en)
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- Hyperpolarized carbon-13 MRI (en)
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