About: HT-2157

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.

Property	Value
dbo:abstract	HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead. (en)
dbo:casNumber	303149-14-6
dbo:fdaUniiCode	J4DRJ9BFS1
dbo:pubchem	1471834
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dbo:wikiPageWikiLink	dbc:Receptor_antagonists dbr:Neuropeptide dbc:Abandoned_drugs dbc:Trifluoromethyl_compounds dbr:Galanin dbr:Antidepressant dbr:Anxiolytic dbr:Receptor_antagonist dbr:Galanin_receptor_3 dbc:Peptides dbr:Serotonin dbr:Cognitive_dysfunction
dbp:alt	Space-filling model (en) Structural formula (en)
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dbp:image	HT-2157 molecule spacefill.png (en)
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dbp:pubchem	1471834 (xsd:integer)
dbp:smiles	c14ccccc4ncc1=N\ccccc2CF (en)
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dbp:stdinchikey	TXCGMRVPXUBHAL-NCELDCMTSA-N (en)
dbp:unii	J4DRJ9BFS1 (en)
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rdfs:comment	HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead. (en)
rdfs:label	HT-2157 (en)
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