About: HDMP-28

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration.

Property	Value
dbo:abstract	HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 has high affinity to SERT, and so behaves as a triple reuptake inhibitor. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration. (en)
dbo:casNumber	(HCl) 231299-82-4
dbo:fdaUniiCode	T52Y9T2U0W
dbo:pubchem	9817261
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dbp:iupacName	Methyl acetate (en)
dbp:legalCa	Schedule III (en)
dbp:legalDe	NpSG (en)
dbp:legalUk	Class B (en)
dbp:molecularWeight	283.365000 (xsd:double)
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dbp:pubchem	9817261 (xsd:integer)
dbp:smiles	O=C[C@H][C@@H]3NCCCC3 (en) O=C[C@H][C@]3CCCCN3 (en)
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gold:hypernym	dbr:Piperidine
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rdfs:comment	HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration. (en)
rdfs:label	HDMP-28 (en)
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