About: H3T3P

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H3T3P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 3rd threonine residue of the histone H3 protein. Pre-existing vs newly generated H3 is distinguished by phosphorylation at threonine 3. H3T3P separates sister chromatids enriched with diverse pools of H3 in order to coordinate asymmetric segregation of "old" H3 into germ stem cells and that male germline activity requires tight regulation of H3T3 phosphorylation.

Property	Value
dbo:abstract	H3T3P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 3rd threonine residue of the histone H3 protein. Pre-existing vs newly generated H3 is distinguished by phosphorylation at threonine 3. H3T3P separates sister chromatids enriched with diverse pools of H3 in order to coordinate asymmetric segregation of "old" H3 into germ stem cells and that male germline activity requires tight regulation of H3T3 phosphorylation. (en)
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dbo:wikiPageWikiLink	dbr:MNase-seq dbr:In_vivo dbr:P53 dbr:Protein_dynamics dbc:Epigenetics dbc:Post-translational_modification dbr:Enzyme dbr:Conformational_change dbr:Lysine dbr:Protein_kinase dbr:Threonine dbr:Tyrosine dbr:ENCODE dbr:Chromatin dbr:Histone_code dbr:Epigenetic dbr:Receptor_(biochemistry) dbr:Histidine dbr:Histone_H3 dbr:Histones dbr:Arginine dbr:ATAC-seq dbr:ChIP-sequencing dbr:Phosphatase dbr:Phosphorylation dbr:Allostery dbr:Immunoprecipitated dbr:Tn5_transposon dbr:File:Amino_acid_phosphorylations.tif
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dcterms:subject	dbc:Epigenetics dbc:Post-translational_modification
rdfs:comment	H3T3P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 3rd threonine residue of the histone H3 protein. Pre-existing vs newly generated H3 is distinguished by phosphorylation at threonine 3. H3T3P separates sister chromatids enriched with diverse pools of H3 in order to coordinate asymmetric segregation of "old" H3 into germ stem cells and that male germline activity requires tight regulation of H3T3 phosphorylation. (en)
rdfs:label	H3T3P (en)
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