About: Group 1 CD1-restricted T cells

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Group 1 CD1-restricted T cells are a heterogeneous group of unconventional T cells defined by their ability to recognize antigens bound on group 1 CD1 molecules (CD1a, CD1b and CD1c) with their TCR. Natural killer T (NKT) cells are a similar population with affinity to CD1d (the only group 2 CD1 molecule). Both groups recognize lipid antigens in contrast to the conventional peptide antigens presented on MHC class 1 and 2 proteins. Most identified T-cells that bind group 1 CD1 proteins are αβ T cells and some are γδ T cells. Both foreign and endogenous lipid antigens activate these cells.

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  • Group 1 CD1-restricted T cells are a heterogeneous group of unconventional T cells defined by their ability to recognize antigens bound on group 1 CD1 molecules (CD1a, CD1b and CD1c) with their TCR. Natural killer T (NKT) cells are a similar population with affinity to CD1d (the only group 2 CD1 molecule). Both groups recognize lipid antigens in contrast to the conventional peptide antigens presented on MHC class 1 and 2 proteins. Most identified T-cells that bind group 1 CD1 proteins are αβ T cells and some are γδ T cells. Both foreign and endogenous lipid antigens activate these cells. The TCR usually recognizes the hydrophilic part of the antigen which protrudes outwards from the CD1 protein after the lipid chains are bound in a groove. Small hydrophobic antigens lacking a polar part have also been shown to activate CD1a-restricted T cells, indicating that in this case the TCR may bind CD1 directly following displacement of nonimmunogenic ligands. (en)
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  • Group 1 CD1-restricted T cells are a heterogeneous group of unconventional T cells defined by their ability to recognize antigens bound on group 1 CD1 molecules (CD1a, CD1b and CD1c) with their TCR. Natural killer T (NKT) cells are a similar population with affinity to CD1d (the only group 2 CD1 molecule). Both groups recognize lipid antigens in contrast to the conventional peptide antigens presented on MHC class 1 and 2 proteins. Most identified T-cells that bind group 1 CD1 proteins are αβ T cells and some are γδ T cells. Both foreign and endogenous lipid antigens activate these cells. (en)
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  • Group 1 CD1-restricted T cells (en)
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