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- In molecular biology, glycoside hydrolase family 89 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. Glycoside hydrolase family 89 CAZY GH_89 includes enzymes with α-N-acetylglucosaminidase EC 3.2.1.50 activity. The enzyme consist of three structural domains, the N-terminal domain has an alpha-beta fold, the central domain has a TIM barrel fold, and the C-terminal domain has an all alpha helical fold. Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations. (en)
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- 6048 (xsd:nonNegativeInteger)
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- family 89 glycoside hydrolase from clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin (en)
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- Alpha-N-acetylglucosaminidase C-terminal domain (en)
- Alpha-N-acetylglucosaminidase N-terminal domain (en)
- Alpha-N-acetylglucosaminidase tim-barrel domain (en)
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- PF05089 (en)
- PF12971 (en)
- PF12972 (en)
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- NAGLU (en)
- NAGLU_C (en)
- NAGLU_N (en)
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| rdfs:comment
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- In molecular biology, glycoside hydrolase family 89 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. (en)
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- Glycoside hydrolase family 89 (en)
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