About: Ganirelix

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilization.

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dbo:abstract
  • Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilization. GnRH agonists are also sometimes used in reproductive therapy, as well as to treat disorders involving sex-steroid hormones, such as endometriosis. One advantage of using GnRH antagonists is that repeated administration of GnRH agonists results in decreased levels of gonadotropins and sex steroids due to desensitization of the pituitary. This is avoided when using GnRH antagonists such as ganirelix. The success of ganirelix in reproductive therapy has been shown to be comparable to that when using GnRH agonists. (en)
  • Il ganirelix acetato (o diacetato) è un antagonista del GnRH selettivo dell'ormone di rilascio delle gonadotropine (GnRH) impiegato come trattamento farmacologico della riproduzione assistita per controllare l'ovulazione. Il farmaco agisce bloccando l'azione del GnRH sulla ipofisi, così rapidamente da sopprimere la produzione e l'azione degli ormoni LH e FSH. Il ganirelix è usato nel trattamento della infertilità per prevenire l'ovulazione prematura causata dalla raccolta di ovociti immaturi, per essere utilizzati nelle procedure di fecondazione in vitro. (it)
dbo:alternativeName
  • Orgalutran, Antagon, others (en)
dbo:bioavailability
  • 91.099998 (xsd:float)
dbo:casNumber
  • 124904-93-4
dbo:chEMBL
  • 1251
dbo:class
dbo:drugbank
  • DB06785
dbo:fdaUniiCode
  • IX503L9WN0
dbo:kegg
  • D04302
  • D08010
dbo:pubchem
  • 16186319
dbo:thumbnail
dbo:wikiPageExternalLink
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  • 9526638 (xsd:integer)
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  • 11602 (xsd:nonNegativeInteger)
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  • 1106834632 (xsd:integer)
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dbp:atcPrefix
  • H01 (en)
dbp:atcSuffix
  • CC01 (en)
dbp:bioavailability
  • 91.1
dbp:c
  • 80 (xsd:integer)
dbp:casNumber
  • 124904 (xsd:integer)
dbp:chembl
  • 1251 (xsd:integer)
dbp:chemspiderid
  • 16736620 (xsd:integer)
dbp:cl
  • 1 (xsd:integer)
dbp:class
dbp:dailymedid
  • Ganirelix (en)
dbp:drugbank
  • DB06785 (en)
dbp:eliminationHalfLife
  • 58320.0
dbp:excretion
  • Feces: 75% (en)
  • Urine: 22% (en)
dbp:h
  • 113 (xsd:integer)
dbp:index2Label
  • as salt (en)
dbp:iupacName
  • -1 (xsd:integer)
dbp:iupharLigand
  • 3877 (xsd:integer)
dbp:kegg
  • D04302 (en)
  • D08010 (en)
dbp:legalAu
  • S4 (en)
dbp:legalUs
  • Rx-only (en)
dbp:licenceEu
  • yes (en)
dbp:n
  • 18 (xsd:integer)
dbp:o
  • 13 (xsd:integer)
dbp:pregnancyAu
  • D (en)
dbp:pregnancyUs
  • X (en)
dbp:proteinBound
  • 81.9
dbp:pubchem
  • 16186319 (xsd:integer)
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dbp:smiles
  • CCNCNCC (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • GJNXBNATEDXMAK-PFLSVRRQSA-N (en)
dbp:tradename
  • Orgalutran, Antagon, others (en)
dbp:unii
  • IX503L9WN0 (en)
dbp:verifiedfields
  • changed (en)
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  • 461118874 (xsd:integer)
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  • 250 (xsd:integer)
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gold:hypernym
rdf:type
rdfs:comment
  • Il ganirelix acetato (o diacetato) è un antagonista del GnRH selettivo dell'ormone di rilascio delle gonadotropine (GnRH) impiegato come trattamento farmacologico della riproduzione assistita per controllare l'ovulazione. Il farmaco agisce bloccando l'azione del GnRH sulla ipofisi, così rapidamente da sopprimere la produzione e l'azione degli ormoni LH e FSH. Il ganirelix è usato nel trattamento della infertilità per prevenire l'ovulazione prematura causata dalla raccolta di ovociti immaturi, per essere utilizzati nelle procedure di fecondazione in vitro. (it)
  • Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilization. (en)
rdfs:label
  • Ganirelix (en)
  • Ganirelix (it)
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prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
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