An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility. Because it has magnetic properties, gadoteric acid develops a magnetic moment when put under a magnetic field, which increases the signal intensity (brightness) of tissues during MRI imaging.

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dbo:abstract
  • Gadotersäure, oft auch als Gd-DOTA bezeichnet, ist der internationale Freiname für ein diagnostisch genutztes Kontrastmittel, das in der Magnetresonanztomografie (MRT) verwendet wird. (de)
  • Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility. Because it has magnetic properties, gadoteric acid develops a magnetic moment when put under a magnetic field, which increases the signal intensity (brightness) of tissues during MRI imaging. (en)
  • L'acide gadotérique, commercialisé sous le nom de Dotarem entre autres, est un agent de contraste pour l'IRM à base de gadolinium (GBCA) macrocyclique. Il se compose d'un ion gadolinium (Gd 3+) chélaté par l'acide organique DOTA, administré sous forme de sel de méglumine (gadoterate meglumine). Le gadolinium étant paramagnétique, il développe un moment magnétique lorsqu'il est soumis à un champ magnétique en IRM, et se liant à une molécule d'eau réduit le temps de relaxation T1 (et dans une certaine mesure T2 & T2*) de ses protons , augmentant l'intensité du signal (luminosité). (fr)
dbo:alternativeName
  • Artirem, Dotarem, Clariscan, others (en)
dbo:casNumber
  • 72573-82-1
dbo:chEBI
  • 73732
dbo:chEMBL
  • 3833326
dbo:drugbank
  • DB09132
dbo:fdaUniiCode
  • QVF9Y6955W
dbo:kegg
  • D08007
dbo:pubchem
  • 158536
dbo:thumbnail
dbo:wikiPageExternalLink
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  • 20362209 (xsd:integer)
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  • 10648 (xsd:nonNegativeInteger)
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  • 1123522006 (xsd:integer)
dbo:wikiPageWikiLink
dbp:atcPrefix
  • V08 (en)
dbp:atcSuffix
  • CA02 (en)
dbp:c
  • 16 (xsd:integer)
dbp:casNumber
  • 72573 (xsd:integer)
dbp:chebi
  • 73732 (xsd:integer)
dbp:chembl
  • 3833326 (xsd:integer)
dbp:chemspiderid
  • 139460 (xsd:integer)
dbp:dailymedid
  • Gadoterate meglumine (en)
dbp:drugbank
  • DB09132 (en)
dbp:gd
  • 1 (xsd:integer)
dbp:h
  • 25 (xsd:integer)
dbp:iupacName
  • gadolinium 2-[4,7,10-tris-1,4,7,10-tetraazacyclododecan-1-yl]acetate (en)
dbp:kegg
  • D08007 (en)
dbp:legalEu
  • Rx-only (en)
dbp:legalStatus
  • Rx-only (en)
dbp:legalUk
  • POM (en)
dbp:legalUs
  • Rx-only (en)
dbp:n
  • 4 (xsd:integer)
dbp:o
  • 8 (xsd:integer)
dbp:pubchem
  • 158536 (xsd:integer)
dbp:routesOfAdministration
dbp:smiles
  • [Gd+3].OCCN1CCNCCNCCNCC1 (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • GFSTXYOTEVLASN-UHFFFAOYSA-K (en)
dbp:synonyms
  • DOTA-Gd (en)
dbp:tradename
  • Artirem, Dotarem, Clariscan, others (en)
dbp:unii
  • QVF9Y6955W (en)
dbp:usan
  • Gadoterate meglumine (en)
dbp:verifiedfields
  • changed (en)
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  • 407376289 (xsd:integer)
dbp:watchedfields
  • changed (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Gadotersäure, oft auch als Gd-DOTA bezeichnet, ist der internationale Freiname für ein diagnostisch genutztes Kontrastmittel, das in der Magnetresonanztomografie (MRT) verwendet wird. (de)
  • Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility. Because it has magnetic properties, gadoteric acid develops a magnetic moment when put under a magnetic field, which increases the signal intensity (brightness) of tissues during MRI imaging. (en)
  • L'acide gadotérique, commercialisé sous le nom de Dotarem entre autres, est un agent de contraste pour l'IRM à base de gadolinium (GBCA) macrocyclique. Il se compose d'un ion gadolinium (Gd 3+) chélaté par l'acide organique DOTA, administré sous forme de sel de méglumine (gadoterate meglumine). Le gadolinium étant paramagnétique, il développe un moment magnétique lorsqu'il est soumis à un champ magnétique en IRM, et se liant à une molécule d'eau réduit le temps de relaxation T1 (et dans une certaine mesure T2 & T2*) de ses protons , augmentant l'intensité du signal (luminosité). (fr)
rdfs:label
  • Kyselina gadoterová (cs)
  • Gadotersäure (de)
  • Gadoteric acid (en)
  • Acide gadotérique (fr)
owl:sameAs
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foaf:depiction
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