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In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.

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dbo:abstract
  • In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold. (en)
dbo:symbol
  • GHMP_kinases_C
  • GHMP_kinases_N
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  • 3425 (xsd:nonNegativeInteger)
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  • 1032255022 (xsd:integer)
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dbp:caption
  • crystal structure of the streptococcus pneumoniae phosphomevalonate kinase (en)
  • pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (en)
dbp:interpro
  • IPR006204 (en)
  • IPR013750 (en)
dbp:name
  • GHMP kinases C terminal (en)
  • GHMP kinases N terminal domain (en)
dbp:pfam
  • PF00288 (en)
  • PF08544 (en)
dbp:pfamClan
  • CL0329 (en)
dbp:prosite
  • PDOC00545 (en)
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  • 1 (xsd:integer)
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  • GHMP_kinases_C (en)
  • GHMP_kinases_N (en)
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rdfs:comment
  • In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold. (en)
rdfs:label
  • GHMP kinase family (en)
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