About: Firocoxib

Property	Value
dbo:abstract	Firocoxib sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox). Firocoxib is the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine. Firocoxib was approved for veterinary use in the United States for dogs in July 2004, and for horses in July 2016. Firocoxib is available as a generic medication for horses and for dogs. (en) Firocoxib is een niet-steroïdale ontstekingsremmer (NSAID) voor gebruik bij dieren. Het is op de markt onder de naam Previcox in de vorm van kauwtabletten voor de hond en Equioxx een orale pasta voor paarden, beiden van Merial) Firocoxib behoort tot de zogenaamde "tweede generatie" van NSAID's, de selectieve COX2-remmers. Het is bedoeld voor de verlichting van pijn en ontsteking geassocieerd met artrose bij honden of paarden. Bij orale toediening aan paarden (dosis van 0,1 mg per kg lichaamsgewicht) heeft firocoxib een gemiddelde orale biologische beschikbaarheid van 79%; de gemiddelde eliminatie-halveringstijd is 29,7 uur. Biotransformatie tot inactieve metabolieten gebeurt overwegend in de lever via dealkylering en glucoronidatie; excretie is vooral via de urine, en minder via de gal. Bij honden (dosis van 5 mg per kg lichaamsgewicht) is de orale biobeschikbaarheid gemiddeld 36%, en de eliminatie-halveringstijd 7,59 uur. De eliminatie is vooral via de gal en de gastrointestinale weg. De SMILES-string van firocoxib is CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)[S](=O)(=O)C)C. (nl) Il firocoxib è un farmaco antinfiammatorio non steroideo, appartenente alla classe degli inibitori selettivi della COX-2, utilizzato a scopo veterinario, in particolare per la cura degli stati infiammatori del cane e del cavallo. Il farmaco è venduto dalla società farmaceutica Merial con il nome commerciale di Previcox per cane e Equioxx per cavallo, ed è disponibile sia in una formulazione orale sia in fiale. (it)
dbo:alternativeName	Equioxx, Previcox (en)
dbo:casNumber	189954-96-9
dbo:chEBI	76136
dbo:chEMBL	69998
dbo:drugbank	DB09217
dbo:fdaUniiCode	Y6V2W4S4WT
dbo:kegg	D03712
dbo:pubchem	208910
dbo:thumbnail	wiki-commons:Special:FilePath/Firocoxib.svg?width=300
dbo:wikiPageExternalLink	https://druginfo.nlm.nih.gov/drugportal/name/firocoxib
dbo:wikiPageID	16961703 (xsd:integer)
dbo:wikiPageLength	8622 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1118728209 (xsd:integer)
dbo:wikiPageWikiLink	dbc:COX-2_inhibitors dbc:Ethers dbr:Oral_administration dbc:Benzosulfones dbc:Cyclopropyl_compounds dbr:Food_and_Drug_Administration dbr:Nonsteroidal_anti-inflammatory_drug dbc:Furanones dbc:Equine_medications dbc:Nonsteroidal_anti-inflammatory_drugs dbc:Dog_medications dbr:COX-2_inhibitor dbr:Generic_medication
dbp:alt	Firocoxib molecule (en)
dbp:atcPrefix	M01 (en)
dbp:atcSuffix	AH90 (en)
dbp:atcvet	yes (en)
dbp:c	17 (xsd:integer)
dbp:casNumber	189954 (xsd:integer)
dbp:chebi	76136 (xsd:integer)
dbp:chembl	69998 (xsd:integer)
dbp:chemspiderid	181008 (xsd:integer)
dbp:dailymedid	Firocoxib (en)
dbp:drugbank	DB09217 (en)
dbp:h	20 (xsd:integer)
dbp:image	Firocoxib-3D-spacefill.png (en)
dbp:iupacName	3 (xsd:integer)
dbp:kegg	D03712 (en)
dbp:legalAu	S4 (en)
dbp:legalEu	Rx-only (en)
dbp:legalStatus	Veterinary use only (en)
dbp:legalUk	POM (en)
dbp:legalUs	Rx-only (en)
dbp:o	5 (xsd:integer)
dbp:pubchem	208910 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:s	1 (xsd:integer)
dbp:smiles	O=C2OCC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	FULAPETWGIGNMT-UHFFFAOYSA-N (en)
dbp:tradename	Equioxx, Previcox (en)
dbp:unii	Y6V2W4S4WT (en)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	443742691 (xsd:integer)
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dcterms:subject	dbc:COX-2_inhibitors dbc:Ethers dbc:Benzosulfones dbc:Cyclopropyl_compounds dbc:Furanones dbc:Equine_medications dbc:Nonsteroidal_anti-inflammatory_drugs dbc:Dog_medications
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCOX-2Inhibitors yago:WikicatCyclopropanes yago:WikicatVeterinaryDrugs yago:WikicatNon-steroidalAnti-inflammatoryDrugs yago:Agent114778436 yago:Anesthetic102710766 yago:Anti-inflammatory102721538 yago:CausalAgent100007347 yago:Cyclopropane103155661 yago:Drug103247620 yago:GeneralAnesthetic103433434 yago:InhalationAnesthetic103570838 yago:Inhibitor114724436 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 yago:WikicatEquineMedications umbel-rc:DrugProduct
rdfs:comment	Firocoxib sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox). Firocoxib is the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine. Firocoxib was approved for veterinary use in the United States for dogs in July 2004, and for horses in July 2016. Firocoxib is available as a generic medication for horses and for dogs. (en) Il firocoxib è un farmaco antinfiammatorio non steroideo, appartenente alla classe degli inibitori selettivi della COX-2, utilizzato a scopo veterinario, in particolare per la cura degli stati infiammatori del cane e del cavallo. Il farmaco è venduto dalla società farmaceutica Merial con il nome commerciale di Previcox per cane e Equioxx per cavallo, ed è disponibile sia in una formulazione orale sia in fiale. (it) Firocoxib is een niet-steroïdale ontstekingsremmer (NSAID) voor gebruik bij dieren. Het is op de markt onder de naam Previcox in de vorm van kauwtabletten voor de hond en Equioxx een orale pasta voor paarden, beiden van Merial) Firocoxib behoort tot de zogenaamde "tweede generatie" van NSAID's, de selectieve COX2-remmers. Het is bedoeld voor de verlichting van pijn en ontsteking geassocieerd met artrose bij honden of paarden. De SMILES-string van firocoxib is CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)[S](=O)(=O)C)C. (nl)
rdfs:label	Firocoxib (en) Firocoxib (it) Firocoxib (nl)
owl:sameAs	freebase:Firocoxib yago-res:Firocoxib wikidata:Firocoxib dbpedia-fa:Firocoxib dbpedia-it:Firocoxib dbpedia-nl:Firocoxib dbpedia-sh:Firocoxib dbpedia-sr:Firocoxib dbpedia-vi:Firocoxib https://global.dbpedia.org/id/vcDu
prov:wasDerivedFrom	wikipedia-en:Firocoxib?oldid=1118728209&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Firocoxib-3D-spacefill.png wiki-commons:Special:FilePath/Firocoxib.svg
foaf:isPrimaryTopicOf	wikipedia-en:Firocoxib
is dbo:wikiPageRedirects of	dbr:Equioxx dbr:ATCvet_code_QM01AH90
is dbo:wikiPageWikiLink of	dbr:Equine_gastric_ulcer_syndrome dbr:Nonsteroidal_anti-inflammatory_drug dbr:Equioxx dbr:ATCvet_code_QM01AH90 dbr:ATC_code_M01 dbr:Laminitis dbr:List_of_drugs:_Fi dbr:Treatment_of_equine_lameness
is foaf:primaryTopic of	wikipedia-en:Firocoxib