About: Esreboxetine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Esreboxetine (developmental code names AXS-14, PNU-165442G) is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (S,S)-(+)-enantiomer of reboxetine and is even more selective as a norepinephrine reuptake inhibitor in comparison. However, recently it has been found that esreboxetine could be effective in fibromyalgia patients.

Property	Value
dbo:abstract	Esreboxetine (developmental code names AXS-14, PNU-165442G) is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (S,S)-(+)-enantiomer of reboxetine and is even more selective as a norepinephrine reuptake inhibitor in comparison. However, recently it has been found that esreboxetine could be effective in fibromyalgia patients. (en)
dbo:casNumber	98819-76-2
dbo:fdaUniiCode	L8S50ZY490
dbo:kegg	D09340
dbo:pubchem	65856
dbo:thumbnail	wiki-commons:Special:FilePath/Esreboxetine.svg?width=300
dbo:wikiPageID	26476724 (xsd:integer)
dbo:wikiPageLength	4423 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1082990610 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Enantiomer dbr:Norepinephrine_reuptake_inhibitor dbr:Pfizer dbc:Pfizer_brands dbc:Phenol_ethers dbr:Oral_administration dbr:Neuropathic_pain dbc:Enantiopure_drugs dbr:Fibromyalgia dbc:Morpholines dbc:Norepinephrine_reuptake_inhibitors dbr:Binding_selectivity dbr:Reboxetine
dbp:atcPrefix	None (en)
dbp:c	19 (xsd:integer)
dbp:casNumber	98819 (xsd:integer)
dbp:chemspiderid	59268 (xsd:integer)
dbp:h	23 (xsd:integer)
dbp:iupacName	-2 (xsd:integer) methyl]morpholine (en)
dbp:iupharLigand	4808 (xsd:integer)
dbp:kegg	D09340 (en)
dbp:legalStatus	Uncontrolled (en)
dbp:n	1 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pubchem	65856 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:smiles	CCOC1=CC=CC=C1O[C@H]C3=CC=CC=C3 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	CBQGYUDMJHNJBX-OALUTQOASA-N (en)
dbp:synonyms	AXS-14; PNU-165442G (en)
dbp:unii	L8S50ZY490 (en)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	451553392 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:width	150 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Analgesic-stub dbt:Analgesics dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Stimulants dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Monoamine_reuptake_inhibitors
dcterms:subject	dbc:Pfizer_brands dbc:Phenol_ethers dbc:Enantiopure_drugs dbc:Morpholines dbc:Norepinephrine_reuptake_inhibitors
gold:hypernym	dbr:Inhibitor
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatNorepinephrineReuptakeInhibitors yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Inhibitor114724436 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 yago:WikicatEnantiopureDrugs umbel-rc:DrugProduct
rdfs:comment	Esreboxetine (developmental code names AXS-14, PNU-165442G) is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (S,S)-(+)-enantiomer of reboxetine and is even more selective as a norepinephrine reuptake inhibitor in comparison. However, recently it has been found that esreboxetine could be effective in fibromyalgia patients. (en)
rdfs:label	Esreboxetine (en)
owl:sameAs	freebase:Esreboxetine yago-res:Esreboxetine wikidata:Esreboxetine https://global.dbpedia.org/id/4jKkY
prov:wasDerivedFrom	wikipedia-en:Esreboxetine?oldid=1082990610&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Esreboxetine.svg
foaf:isPrimaryTopicOf	wikipedia-en:Esreboxetine
is dbo:wikiPageRedirects of	dbr:PNU-165442G dbr:PNU165442G dbr:PNU_165442G dbr:Esreboxetine_succinate dbr:AXS-14 dbr:AXS14 dbr:AXS_14
is dbo:wikiPageWikiLink of	dbr:List_of_adrenergic_drugs dbr:Norepinephrine_reuptake_inhibitor dbr:Edivoxetine dbr:C19H23NO3 dbr:List_of_drugs:_Eq–Es dbr:PNU-165442G dbr:PNU165442G dbr:PNU_165442G dbr:Esreboxetine_succinate dbr:AXS-14 dbr:AXS14 dbr:AXS_14
is foaf:primaryTopic of	wikipedia-en:Esreboxetine