About: Epi-lipoxin

An Entity of Type: Thing, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Epi-lipoxins are trihydroxy (i.e. containing 3 hydroxyl residues) metabolites of arachidonic acid. They are 15R-epimers of their lipoxin counterparts; that is, the epi-lipoxins, 15-epi-lipoxin A4 (15-epi-LxA4) and 15-epi-lipoxin B4 (15-epi-LXB4), differ from their respective lipoxin A4 (LxA4) and lipoxin B4 (LxB4) epimers in that their 15-hydroxy residue has R rather than S chirality. Formulae for these lipoxins (Lx) are: The counter-regulatory role of the epi-lipoxins in serving as stop signals for diverse inflammation responses is detailed at the lipoxin site.

Property Value
dbo:abstract
  • Epi-lipoxins are trihydroxy (i.e. containing 3 hydroxyl residues) metabolites of arachidonic acid. They are 15R-epimers of their lipoxin counterparts; that is, the epi-lipoxins, 15-epi-lipoxin A4 (15-epi-LxA4) and 15-epi-lipoxin B4 (15-epi-LXB4), differ from their respective lipoxin A4 (LxA4) and lipoxin B4 (LxB4) epimers in that their 15-hydroxy residue has R rather than S chirality. Formulae for these lipoxins (Lx) are: * LxA4: 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-ETE * LxB4: 5S,14R,15S-trihydroxy-6E,8Z,10E,12E-ETE * 15-epi-LxA4: 5S,6R,15R-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid * 15-epi-LxB4: 5S,14R,15R-trihydroxy-6E,8Z,10E,12E-eicosatrienoic acid The two-epi-Lx's as well as the two lx's are nonclassic eicosanoids that, like other members of the specialized pro-resolving mediators class of autocoids, form during and act to resolve inflammatory responses. Synthesis of the lipoxins typically involves a lipoxygenase enzyme which acts to add a 15S-hydroxyl residue to the lipoxin precursor, arachidonic acid, whereas synthesis of the epi-lipoxins involves aspirin-pretreated cyclooxygenase 2 or a cytochrome P450 enzyme which adds a 15R-hydroxyl residue to arachidonic acid. In acknowledgement of the role played by aspirin-treated cyclooxygenase 2 in forming these products, the epi-lipoxins are sometimes termed ATL which stands for Aspirin-Triggered Lipoxins. The counter-regulatory role of the epi-lipoxins in serving as stop signals for diverse inflammation responses is detailed at the lipoxin site. (en)
  • Le Epilipossine sono derivati dell'acido arachidonico, analoghi alle lipossine, che si formano con il blocco di COX-2. (it)
dbo:wikiPageID
  • 14028784 (xsd:integer)
dbo:wikiPageLength
  • 3242 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1048626394 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdfs:comment
  • Le Epilipossine sono derivati dell'acido arachidonico, analoghi alle lipossine, che si formano con il blocco di COX-2. (it)
  • Epi-lipoxins are trihydroxy (i.e. containing 3 hydroxyl residues) metabolites of arachidonic acid. They are 15R-epimers of their lipoxin counterparts; that is, the epi-lipoxins, 15-epi-lipoxin A4 (15-epi-LxA4) and 15-epi-lipoxin B4 (15-epi-LXB4), differ from their respective lipoxin A4 (LxA4) and lipoxin B4 (LxB4) epimers in that their 15-hydroxy residue has R rather than S chirality. Formulae for these lipoxins (Lx) are: The counter-regulatory role of the epi-lipoxins in serving as stop signals for diverse inflammation responses is detailed at the lipoxin site. (en)
rdfs:label
  • Epi-lipoxin (en)
  • Epilipossine (it)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License