About: Ensaculin

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. Animal studies have shown promising nootropic effects, although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure).

Property	Value
dbo:abstract	Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. Animal studies have shown promising nootropic effects, although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure). (en)
dbo:casNumber	155773-59-4
dbo:chEMBL	1963107
dbo:fdaUniiCode	869PGR00AT
dbo:pubchem	208923
dbo:thumbnail	wiki-commons:Special:FilePath/Ensaculin.svg?width=300
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dbo:wikiPageLength	3931 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1083017314 (xsd:integer)
dbo:wikiPageWikiLink	dbr:5HT1A_receptor dbr:Enciprazine dbr:Dementia dbr:Coumarin dbc:N-(2-methoxyphenyl)piperazines dbr:Azaperone dbr:BMY-14802 dbc:Catechol_ethers dbc:Coumarin_drugs dbc:Nootropics dbc:Resorcinol_ethers dbr:Fluanisone dbr:Nootropic dbr:Hypotension dbr:NMDA_antagonist dbr:Mafoprazine
dbp:atcPrefix	none (en)
dbp:c	26 (xsd:integer)
dbp:casNumber	155773 (xsd:integer)
dbp:chembl	1963107 (xsd:integer)
dbp:chemspiderid	181019 (xsd:integer)
dbp:eliminationHalfLife	49320.0
dbp:h	32 (xsd:integer)
dbp:iupacName	7 (xsd:integer)
dbp:molecularWeight	452.543000 (xsd:double)
dbp:n	2 (xsd:integer)
dbp:o	5 (xsd:integer)
dbp:pubchem	208923 (xsd:integer)
dbp:smiles	O=C/4Oc3ccccc3\CC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	FQELZLMTAPJJOL-UHFFFAOYSA-N (en)
dbp:unii	869 (xsd:integer)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	400125842 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:width	240 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Coumarin dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Piperazines dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Anti-dementia_drugs
dcterms:subject	dbc:N-(2-methoxyphenyl)piperazines dbc:Catechol_ethers dbc:Coumarin_drugs dbc:Nootropics dbc:Resorcinol_ethers
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCoumarinDrugs yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:Piperazine103946814 dbo:Drug yago:Substance100020090 yago:Vermifuge104528630 yago:WikicatPiperazines umbel-rc:DrugProduct
rdfs:comment	Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. Animal studies have shown promising nootropic effects, although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being orthostatic hypotension (low blood pressure). (en)
rdfs:label	Ensaculin (en)
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prov:wasDerivedFrom	wikipedia-en:Ensaculin?oldid=1083017314&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Ensaculin.svg
foaf:isPrimaryTopicOf	wikipedia-en:Ensaculin
is dbo:wikiPageWikiLink of	dbr:Enciprazine dbr:Coumarin dbr:BMY-14802 dbr:C26H32N2O5 dbr:List_of_drugs:_Em–Ep
is foaf:primaryTopic of	wikipedia-en:Ensaculin