Sir Edward Hughes (4 July 1919 – 16 October 1998) was an eminent Melbourne colorectal surgeon. He was a professor of surgery at Monash University and served as president of the Royal Australasian College of Surgeons and chairman of the Menzies Foundation. He played a significant role in influencing the Victorian Government to become the first jurisdiction in the world to introduce legislation for the compulsory use of seat belts in motor vehicles.